Adjuvante therapie mit einer n-palmitoylethanol-amin-haltigen creme bei kindern mit atopischem ekzem (atopa-studie)

Translated title of the contribution: Adjuvant treatment of children with atopic eczema with an emollient containing n-palmitoylethanolamine (atopa study)

B. Eberlein, C. Eicke, H. W. Reinhardt, J. Ring

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

The objective of this study was to yield data on the skin care properties of a cream with a unique lamellar matrix containing N-palmitoylethanolamine, and to assess quality of life variables during the management of patients with atopic eczema. In this multi-national, multicenter, observational, non-controlled, prospective cohort study 2456 patients (923 children ≤ 12 years) were enrolled. Outcome was followed over 38 days of adjuvant treatment with the study cream. Combined analysis of erythema, pruritus, excoriation, scaling, li- chenification and dryness showed a significant score reduction by 58.6% at study end for all patients (57.7% for adults ≥ 12 years and 60.5 % for children ≤ 12 years). Patients reported a significant reduction of pruritus on visual analogue scales as soon as 6 days after starting treatment and a further reduction at study end. Sleep quality improved significantly during the study period. Earlier used topical corticosteroids were omitted by 56 % of all patients (53.4% in adults ≥ 12 and 62.5% in children ≤ 12 years) at study end and the average weekly application rate decreased from 7.9 to 3. The tolerance was assessed as very good or good in 92 % of cases by both patients and doctors. This study demonstrates substantial relief of objective and subjective symptoms of atopic eczema after regular skin care with the study cream over a period of 38 days. The requirement for treatment with topical corticosteroids was reduced in a substantial proportion of participants, which has potentially important pharmacoeconomic implications in the management of atopic eczema.

Translated title of the contributionAdjuvant treatment of children with atopic eczema with an emollient containing n-palmitoylethanolamine (atopa study)
Original languageGerman
Pages (from-to)339-341
Number of pages3
JournalAktuelle Dermatologie
Volume35
Issue number8-9
DOIs
StatePublished - 2009

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