Adhesion Molecules ICAM-1 and PECAM-1 as Potential Biomarkers of Central Nervous System Damage in Women Breast Cancer Survivors

Maria Pospelova; Varvara Krasnikova; Olga Fionik; Tatyana Alekseeva; Konstantin Samochernykh; Nataliya Ivanova; Nikita Trofimov; Tatyana Vavilova; Elena Vasilieva; Mariya Topuzova; Alexandra Chaykovskaya; Albina Makhanova; Tatyana Bukkieva; Evgeniya Kayumova; Stephanie Combs; Maxim Shevtsov

doi:10.3390/pathophysiology29010006

Adhesion Molecules ICAM-1 and PECAM-1 as Potential Biomarkers of Central Nervous System Damage in Women Breast Cancer Survivors

Maria Pospelova, Varvara Krasnikova, Olga Fionik, Tatyana Alekseeva, Konstantin Samochernykh, Nataliya Ivanova, Nikita Trofimov, Tatyana Vavilova, Elena Vasilieva, Mariya Topuzova, Alexandra Chaykovskaya, Albina Makhanova, Tatyana Bukkieva, Evgeniya Kayumova, Stephanie Combs, Maxim Shevtsov

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Breast cancer (BC) is the most common tumor in women worldwide with high mortality rates. Surgical methods followed by radio–chemotherapy are used to treat these tumors. Such treatment can lead to various side effects, including neurological complications. The development of a reliable biomarker to predict the onset of CNS complications could improve clinical outcomes. In the current study, ICAM-1 and PECAM-1 serum levels were measured as potential biomarkers in 45 female patients in a long-term follow-up period after breast cancer treatment, and compared to 25 age-matched female healthy volunteers. Serum levels of both biomarkers, ICAM-1 and PECAM-1 were significantly higher in patients after breast cancer treatment and could be associated with cognitive dysfunction, depression, and vestibulocerebellar ataxia. In conclusion, our results provide a first hint that elevated serum levels of ICAM-1 and PECAM-1 could serve as early predictive biomarkers in breast cancer survivors that might help to improve the management of these patients.

Original language	English
Pages (from-to)	52-65
Number of pages	14
Journal	Pathophysiology
Volume	29
Issue number	1
DOIs	https://doi.org/10.3390/pathophysiology29010006
State	Published - Mar 2022
Externally published	Yes

Keywords

Adhesion molecules
Breast cancer
Breast cancer survivors
Central nervous system damage
ICAM-1
Liquid biopsy
PECAM-1
Post-mastectomy pain syndrome

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/pathophysiology29010006

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Pospelova, M., Krasnikova, V., Fionik, O., Alekseeva, T., Samochernykh, K., Ivanova, N., Trofimov, N., Vavilova, T., Vasilieva, E., Topuzova, M., Chaykovskaya, A., Makhanova, A., Bukkieva, T., Kayumova, E., Combs, S., & Shevtsov, M. (2022). Adhesion Molecules ICAM-1 and PECAM-1 as Potential Biomarkers of Central Nervous System Damage in Women Breast Cancer Survivors. Pathophysiology, 29(1), 52-65. https://doi.org/10.3390/pathophysiology29010006

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title = "Adhesion Molecules ICAM-1 and PECAM-1 as Potential Biomarkers of Central Nervous System Damage in Women Breast Cancer Survivors",

abstract = "Breast cancer (BC) is the most common tumor in women worldwide with high mortality rates. Surgical methods followed by radio–chemotherapy are used to treat these tumors. Such treatment can lead to various side effects, including neurological complications. The development of a reliable biomarker to predict the onset of CNS complications could improve clinical outcomes. In the current study, ICAM-1 and PECAM-1 serum levels were measured as potential biomarkers in 45 female patients in a long-term follow-up period after breast cancer treatment, and compared to 25 age-matched female healthy volunteers. Serum levels of both biomarkers, ICAM-1 and PECAM-1 were significantly higher in patients after breast cancer treatment and could be associated with cognitive dysfunction, depression, and vestibulocerebellar ataxia. In conclusion, our results provide a first hint that elevated serum levels of ICAM-1 and PECAM-1 could serve as early predictive biomarkers in breast cancer survivors that might help to improve the management of these patients.",

keywords = "Adhesion molecules, Breast cancer, Breast cancer survivors, Central nervous system damage, ICAM-1, Liquid biopsy, PECAM-1, Post-mastectomy pain syndrome",

author = "Maria Pospelova and Varvara Krasnikova and Olga Fionik and Tatyana Alekseeva and Konstantin Samochernykh and Nataliya Ivanova and Nikita Trofimov and Tatyana Vavilova and Elena Vasilieva and Mariya Topuzova and Alexandra Chaykovskaya and Albina Makhanova and Tatyana Bukkieva and Evgeniya Kayumova and Stephanie Combs and Maxim Shevtsov",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = mar,

doi = "10.3390/pathophysiology29010006",

language = "English",

volume = "29",

pages = "52--65",

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Pospelova, M, Krasnikova, V, Fionik, O, Alekseeva, T, Samochernykh, K, Ivanova, N, Trofimov, N, Vavilova, T, Vasilieva, E, Topuzova, M, Chaykovskaya, A, Makhanova, A, Bukkieva, T, Kayumova, E, Combs, S & Shevtsov, M 2022, 'Adhesion Molecules ICAM-1 and PECAM-1 as Potential Biomarkers of Central Nervous System Damage in Women Breast Cancer Survivors', Pathophysiology, vol. 29, no. 1, pp. 52-65. https://doi.org/10.3390/pathophysiology29010006

TY - JOUR

T1 - Adhesion Molecules ICAM-1 and PECAM-1 as Potential Biomarkers of Central Nervous System Damage in Women Breast Cancer Survivors

AU - Pospelova, Maria

AU - Krasnikova, Varvara

AU - Fionik, Olga

AU - Alekseeva, Tatyana

AU - Samochernykh, Konstantin

AU - Ivanova, Nataliya

AU - Trofimov, Nikita

AU - Vavilova, Tatyana

AU - Vasilieva, Elena

AU - Topuzova, Mariya

AU - Chaykovskaya, Alexandra

AU - Makhanova, Albina

AU - Bukkieva, Tatyana

AU - Kayumova, Evgeniya

AU - Combs, Stephanie

AU - Shevtsov, Maxim

PY - 2022/3

Y1 - 2022/3

N2 - Breast cancer (BC) is the most common tumor in women worldwide with high mortality rates. Surgical methods followed by radio–chemotherapy are used to treat these tumors. Such treatment can lead to various side effects, including neurological complications. The development of a reliable biomarker to predict the onset of CNS complications could improve clinical outcomes. In the current study, ICAM-1 and PECAM-1 serum levels were measured as potential biomarkers in 45 female patients in a long-term follow-up period after breast cancer treatment, and compared to 25 age-matched female healthy volunteers. Serum levels of both biomarkers, ICAM-1 and PECAM-1 were significantly higher in patients after breast cancer treatment and could be associated with cognitive dysfunction, depression, and vestibulocerebellar ataxia. In conclusion, our results provide a first hint that elevated serum levels of ICAM-1 and PECAM-1 could serve as early predictive biomarkers in breast cancer survivors that might help to improve the management of these patients.

AB - Breast cancer (BC) is the most common tumor in women worldwide with high mortality rates. Surgical methods followed by radio–chemotherapy are used to treat these tumors. Such treatment can lead to various side effects, including neurological complications. The development of a reliable biomarker to predict the onset of CNS complications could improve clinical outcomes. In the current study, ICAM-1 and PECAM-1 serum levels were measured as potential biomarkers in 45 female patients in a long-term follow-up period after breast cancer treatment, and compared to 25 age-matched female healthy volunteers. Serum levels of both biomarkers, ICAM-1 and PECAM-1 were significantly higher in patients after breast cancer treatment and could be associated with cognitive dysfunction, depression, and vestibulocerebellar ataxia. In conclusion, our results provide a first hint that elevated serum levels of ICAM-1 and PECAM-1 could serve as early predictive biomarkers in breast cancer survivors that might help to improve the management of these patients.

KW - Adhesion molecules

KW - Breast cancer

KW - Breast cancer survivors

KW - Central nervous system damage

KW - ICAM-1

KW - Liquid biopsy

KW - PECAM-1

KW - Post-mastectomy pain syndrome

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U2 - 10.3390/pathophysiology29010006

DO - 10.3390/pathophysiology29010006

M3 - Article

AN - SCOPUS:85125096130

SN - 0928-4680

VL - 29

SP - 52

EP - 65

JO - Pathophysiology

JF - Pathophysiology

IS - 1

ER -

Adhesion Molecules ICAM-1 and PECAM-1 as Potential Biomarkers of Central Nervous System Damage in Women Breast Cancer Survivors

Abstract

Keywords

UN SDGs

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