Activity of rat cytosolic thioredoxin reductase is strongly decreased by trans-[bis(2-amino-5-methylthiazole)tetrachlororuthenate(III)]: First report of relevant thioredoxin reductase inhibition for a ruthenium compound

Pasquale Mura; Mercedes Camalli; Alberto Bindoli; Francesca Sorrentino; Angela Casini; Chiara Gabbiani; Maddalena Corsini; Piero Zanello; Maria Pia Rigobello; Luigi Messori

doi:10.1021/jm0708578

Activity of rat cytosolic thioredoxin reductase is strongly decreased by trans-[bis(2-amino-5-methylthiazole)tetrachlororuthenate(III)]: First report of relevant thioredoxin reductase inhibition for a ruthenium compound

Pasquale Mura
, Mercedes Camalli
, Alberto Bindoli
, Francesca Sorrentino
, Angela Casini
, Chiara Gabbiani
, Maddalena Corsini
, Piero Zanello
, Maria Pia Rigobello
, Luigi Messori

IMM-CNR
University of Padova
University of Florence
University of Siena

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

A novel "Keppler type" ruthenium(III) compound trans-[bis(2-amino 5-methylthiazole)tetrachlororuthenate(III)] 1, of potential interest as an anticancer agent, was designed, synthesized, and characterized. Its interactions with various proteins were analyzed, including the selenoenzyme thioredoxin reductase, an emerging target for anticancer metallodrugs. The selective inhibition of the cytosolic form of this selenoenzyme was documented, this being the first report of significant thioredoxin reductase inhibition by a ruthenium compound.

Original language	English
Pages (from-to)	5871-5874
Number of pages	4
Journal	Journal of Medicinal Chemistry
Volume	50
Issue number	24
DOIs	https://doi.org/10.1021/jm0708578
State	Published - 29 Nov 2007
Externally published	Yes

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Mura, P., Camalli, M., Bindoli, A., Sorrentino, F., Casini, A., Gabbiani, C., Corsini, M., Zanello, P., Rigobello, M. P., & Messori, L. (2007). Activity of rat cytosolic thioredoxin reductase is strongly decreased by trans-[bis(2-amino-5-methylthiazole)tetrachlororuthenate(III)]: First report of relevant thioredoxin reductase inhibition for a ruthenium compound. Journal of Medicinal Chemistry, 50(24), 5871-5874. https://doi.org/10.1021/jm0708578

@article{2d11c316da6c49c6b59771f972e65393,

title = "Activity of rat cytosolic thioredoxin reductase is strongly decreased by trans-[bis(2-amino-5-methylthiazole)tetrachlororuthenate(III)]: First report of relevant thioredoxin reductase inhibition for a ruthenium compound",

abstract = "A novel {"}Keppler type{"} ruthenium(III) compound trans-[bis(2-amino 5-methylthiazole)tetrachlororuthenate(III)] 1, of potential interest as an anticancer agent, was designed, synthesized, and characterized. Its interactions with various proteins were analyzed, including the selenoenzyme thioredoxin reductase, an emerging target for anticancer metallodrugs. The selective inhibition of the cytosolic form of this selenoenzyme was documented, this being the first report of significant thioredoxin reductase inhibition by a ruthenium compound.",

author = "Pasquale Mura and Mercedes Camalli and Alberto Bindoli and Francesca Sorrentino and Angela Casini and Chiara Gabbiani and Maddalena Corsini and Piero Zanello and Rigobello, \{Maria Pia\} and Luigi Messori",

year = "2007",

month = nov,

day = "29",

doi = "10.1021/jm0708578",

language = "English",

volume = "50",

pages = "5871--5874",

journal = "Journal of Medicinal Chemistry",

issn = "0022-2623",

publisher = "American Chemical Society",

number = "24",

}

Mura, P, Camalli, M, Bindoli, A, Sorrentino, F, Casini, A, Gabbiani, C, Corsini, M, Zanello, P, Rigobello, MP & Messori, L 2007, 'Activity of rat cytosolic thioredoxin reductase is strongly decreased by trans-[bis(2-amino-5-methylthiazole)tetrachlororuthenate(III)]: First report of relevant thioredoxin reductase inhibition for a ruthenium compound', Journal of Medicinal Chemistry, vol. 50, no. 24, pp. 5871-5874. https://doi.org/10.1021/jm0708578

Activity of rat cytosolic thioredoxin reductase is strongly decreased by trans-[bis(2-amino-5-methylthiazole)tetrachlororuthenate(III)]: First report of relevant thioredoxin reductase inhibition for a ruthenium compound. / Mura, Pasquale; Camalli, Mercedes; Bindoli, Alberto et al.
In: Journal of Medicinal Chemistry, Vol. 50, No. 24, 29.11.2007, p. 5871-5874.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Activity of rat cytosolic thioredoxin reductase is strongly decreased by trans-[bis(2-amino-5-methylthiazole)tetrachlororuthenate(III)]

T2 - First report of relevant thioredoxin reductase inhibition for a ruthenium compound

AU - Mura, Pasquale

AU - Camalli, Mercedes

AU - Bindoli, Alberto

AU - Sorrentino, Francesca

AU - Casini, Angela

AU - Gabbiani, Chiara

AU - Corsini, Maddalena

AU - Zanello, Piero

AU - Rigobello, Maria Pia

AU - Messori, Luigi

PY - 2007/11/29

Y1 - 2007/11/29

N2 - A novel "Keppler type" ruthenium(III) compound trans-[bis(2-amino 5-methylthiazole)tetrachlororuthenate(III)] 1, of potential interest as an anticancer agent, was designed, synthesized, and characterized. Its interactions with various proteins were analyzed, including the selenoenzyme thioredoxin reductase, an emerging target for anticancer metallodrugs. The selective inhibition of the cytosolic form of this selenoenzyme was documented, this being the first report of significant thioredoxin reductase inhibition by a ruthenium compound.

AB - A novel "Keppler type" ruthenium(III) compound trans-[bis(2-amino 5-methylthiazole)tetrachlororuthenate(III)] 1, of potential interest as an anticancer agent, was designed, synthesized, and characterized. Its interactions with various proteins were analyzed, including the selenoenzyme thioredoxin reductase, an emerging target for anticancer metallodrugs. The selective inhibition of the cytosolic form of this selenoenzyme was documented, this being the first report of significant thioredoxin reductase inhibition by a ruthenium compound.

UR - https://www.scopus.com/pages/publications/37849024094

U2 - 10.1021/jm0708578

DO - 10.1021/jm0708578

M3 - Article

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AN - SCOPUS:37849024094

SN - 0022-2623

VL - 50

SP - 5871

EP - 5874

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

IS - 24

ER -

Mura P, Camalli M, Bindoli A, Sorrentino F, Casini A, Gabbiani C et al. Activity of rat cytosolic thioredoxin reductase is strongly decreased by trans-[bis(2-amino-5-methylthiazole)tetrachlororuthenate(III)]: First report of relevant thioredoxin reductase inhibition for a ruthenium compound. Journal of Medicinal Chemistry. 2007 Nov 29;50(24):5871-5874. doi: 10.1021/jm0708578

Activity of rat cytosolic thioredoxin reductase is strongly decreased by trans-[bis(2-amino-5-methylthiazole)tetrachlororuthenate(III)]: First report of relevant thioredoxin reductase inhibition for a ruthenium compound

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