TY - JOUR
T1 - Activity of rat cytosolic thioredoxin reductase is strongly decreased by trans-[bis(2-amino-5-methylthiazole)tetrachlororuthenate(III)]
T2 - First report of relevant thioredoxin reductase inhibition for a ruthenium compound
AU - Mura, Pasquale
AU - Camalli, Mercedes
AU - Bindoli, Alberto
AU - Sorrentino, Francesca
AU - Casini, Angela
AU - Gabbiani, Chiara
AU - Corsini, Maddalena
AU - Zanello, Piero
AU - Rigobello, Maria Pia
AU - Messori, Luigi
PY - 2007/11/29
Y1 - 2007/11/29
N2 - A novel "Keppler type" ruthenium(III) compound trans-[bis(2-amino 5-methylthiazole)tetrachlororuthenate(III)] 1, of potential interest as an anticancer agent, was designed, synthesized, and characterized. Its interactions with various proteins were analyzed, including the selenoenzyme thioredoxin reductase, an emerging target for anticancer metallodrugs. The selective inhibition of the cytosolic form of this selenoenzyme was documented, this being the first report of significant thioredoxin reductase inhibition by a ruthenium compound.
AB - A novel "Keppler type" ruthenium(III) compound trans-[bis(2-amino 5-methylthiazole)tetrachlororuthenate(III)] 1, of potential interest as an anticancer agent, was designed, synthesized, and characterized. Its interactions with various proteins were analyzed, including the selenoenzyme thioredoxin reductase, an emerging target for anticancer metallodrugs. The selective inhibition of the cytosolic form of this selenoenzyme was documented, this being the first report of significant thioredoxin reductase inhibition by a ruthenium compound.
UR - http://www.scopus.com/inward/record.url?scp=37849024094&partnerID=8YFLogxK
U2 - 10.1021/jm0708578
DO - 10.1021/jm0708578
M3 - Article
C2 - 17975904
AN - SCOPUS:37849024094
SN - 0022-2623
VL - 50
SP - 5871
EP - 5874
JO - Journal of Medicinal Chemistry
JF - Journal of Medicinal Chemistry
IS - 24
ER -