Activity-based probes for studying the activity of flavin-dependent oxidases and for the protein target profiling of monoamine oxidase inhibitors

Joanna M. Krysiak; Johannes Kreuzer; Peter MacHeroux; Albin Hermetter; Stephan A. Sieber; Rolf Breinbauer

doi:10.1002/anie.201201955

Activity-based probes for studying the activity of flavin-dependent oxidases and for the protein target profiling of monoamine oxidase inhibitors

Joanna M. Krysiak, Johannes Kreuzer, Peter MacHeroux, Albin Hermetter, Stephan A. Sieber, Rolf Breinbauer

Chair of Organic Chemistry II

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

High profile: New activity-based protein profiling (ABPP) probes have been designed that target exclusively monoamine oxidases A and B within living cells (see picture; FAD=flavin adenine dinucleotide, FMN=flavin monodinucleotide). With these probes it could be shown that the MAO inhibitor deprenyl, which is in clinical use against Parkinson's disease, shows unique protein specificity despite its covalent mechanism of action.

Original language	English
Pages (from-to)	7035-7040
Number of pages	6
Journal	Angewandte Chemie International Edition in English
Volume	51
Issue number	28
DOIs	https://doi.org/10.1002/anie.201201955
State	Published - 9 Jul 2012

Keywords

activity-based probes
deprenyl
flavin cofactor
monoamine oxidases
proteomics

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10.1002/anie.201201955

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abstract = "High profile: New activity-based protein profiling (ABPP) probes have been designed that target exclusively monoamine oxidases A and B within living cells (see picture; FAD=flavin adenine dinucleotide, FMN=flavin monodinucleotide). With these probes it could be shown that the MAO inhibitor deprenyl, which is in clinical use against Parkinson's disease, shows unique protein specificity despite its covalent mechanism of action.",

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Activity-based probes for studying the activity of flavin-dependent oxidases and for the protein target profiling of monoamine oxidase inhibitors. / Krysiak, Joanna M.; Kreuzer, Johannes; MacHeroux, Peter et al.
In: Angewandte Chemie International Edition in English, Vol. 51, No. 28, 09.07.2012, p. 7035-7040.

Research output: Contribution to journal › Article › peer-review

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T1 - Activity-based probes for studying the activity of flavin-dependent oxidases and for the protein target profiling of monoamine oxidase inhibitors

AU - Krysiak, Joanna M.

AU - Kreuzer, Johannes

AU - MacHeroux, Peter

AU - Hermetter, Albin

AU - Sieber, Stephan A.

AU - Breinbauer, Rolf

PY - 2012/7/9

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AB - High profile: New activity-based protein profiling (ABPP) probes have been designed that target exclusively monoamine oxidases A and B within living cells (see picture; FAD=flavin adenine dinucleotide, FMN=flavin monodinucleotide). With these probes it could be shown that the MAO inhibitor deprenyl, which is in clinical use against Parkinson's disease, shows unique protein specificity despite its covalent mechanism of action.

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Activity-based probes for studying the activity of flavin-dependent oxidases and for the protein target profiling of monoamine oxidase inhibitors

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Keywords

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