Acne-associated syndromes: Models for better understanding of acne pathogenesis

W. Chen; B. Obermayer-Pietsch; J. B. Hong; B. C. Melnik; O. Yamasaki; C. Dessinioti; Q. Ju; A. I. Liakou; S. Al-Khuzaei; A. Katsambas; J. Ring; C. C. Zouboulis

doi:10.1111/j.1468-3083.2010.03937.x

Acne-associated syndromes: Models for better understanding of acne pathogenesis

W. Chen, B. Obermayer-Pietsch, J. B. Hong, B. C. Melnik, O. Yamasaki, C. Dessinioti, Q. Ju, A. I. Liakou, S. Al-Khuzaei, A. Katsambas, J. Ring, C. C. Zouboulis

TUM Emeriti of Excellence

Research output: Contribution to journal › Review article › peer-review

94 Scopus citations

Abstract

Acne, one of the most common skin disorders, is also a cardinal component of many systemic diseases or syndromes. Their association illustrates the nature of these diseases and is indicative of the pathogenesis of acne. Congenital adrenal hyperplasia (CAH) and seborrhoea-acne-hirsutism-androgenetic alopecia (SAHA) syndrome highlight the role of androgen steroids, while polycystic ovary (PCO) and hyperandrogenism-insulin resistance-acanthosis nigricans (HAIR-AN) syndromes indicate insulin resistance in acne. Apert syndrome with increased fibroblast growth factor receptor 2 (FGFR2) signalling results in follicular hyperkeratinization and sebaceous gland hypertrophy in acne. Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) and pyogenic arthritis-pyoderma gangrenosum-acne (PAPA) syndromes highlight the attributes of inflammation to acne formation. Advances in the understanding of the manifestation and molecular mechanisms of these syndromes will help to clarify acne pathogenesis and develop novel therapeutic modalities.

Original language	English
Pages (from-to)	637-646
Number of pages	10
Journal	Journal of the European Academy of Dermatology and Venereology
Volume	25
Issue number	6
DOIs	https://doi.org/10.1111/j.1468-3083.2010.03937.x
State	Published - Jun 2011

Keywords

Apert syndrome
PAPA syndrome
PCO syndrome
SAPHO syndrome
acne
insulin resistance

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1468-3083.2010.03937.x

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Chen, W., Obermayer-Pietsch, B., Hong, J. B., Melnik, B. C., Yamasaki, O., Dessinioti, C., Ju, Q., Liakou, A. I., Al-Khuzaei, S., Katsambas, A., Ring, J., & Zouboulis, C. C. (2011). Acne-associated syndromes: Models for better understanding of acne pathogenesis. Journal of the European Academy of Dermatology and Venereology, 25(6), 637-646. https://doi.org/10.1111/j.1468-3083.2010.03937.x

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abstract = "Acne, one of the most common skin disorders, is also a cardinal component of many systemic diseases or syndromes. Their association illustrates the nature of these diseases and is indicative of the pathogenesis of acne. Congenital adrenal hyperplasia (CAH) and seborrhoea-acne-hirsutism-androgenetic alopecia (SAHA) syndrome highlight the role of androgen steroids, while polycystic ovary (PCO) and hyperandrogenism-insulin resistance-acanthosis nigricans (HAIR-AN) syndromes indicate insulin resistance in acne. Apert syndrome with increased fibroblast growth factor receptor 2 (FGFR2) signalling results in follicular hyperkeratinization and sebaceous gland hypertrophy in acne. Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) and pyogenic arthritis-pyoderma gangrenosum-acne (PAPA) syndromes highlight the attributes of inflammation to acne formation. Advances in the understanding of the manifestation and molecular mechanisms of these syndromes will help to clarify acne pathogenesis and develop novel therapeutic modalities.",

keywords = "Apert syndrome, PAPA syndrome, PCO syndrome, SAPHO syndrome, acne, insulin resistance",

author = "W. Chen and B. Obermayer-Pietsch and Hong, {J. B.} and Melnik, {B. C.} and O. Yamasaki and C. Dessinioti and Q. Ju and Liakou, {A. I.} and S. Al-Khuzaei and A. Katsambas and J. Ring and Zouboulis, {C. C.}",

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Chen, W, Obermayer-Pietsch, B, Hong, JB, Melnik, BC, Yamasaki, O, Dessinioti, C, Ju, Q, Liakou, AI, Al-Khuzaei, S, Katsambas, A, Ring, J & Zouboulis, CC 2011, 'Acne-associated syndromes: Models for better understanding of acne pathogenesis', Journal of the European Academy of Dermatology and Venereology, vol. 25, no. 6, pp. 637-646. https://doi.org/10.1111/j.1468-3083.2010.03937.x

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AU - Ju, Q.

AU - Liakou, A. I.

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AB - Acne, one of the most common skin disorders, is also a cardinal component of many systemic diseases or syndromes. Their association illustrates the nature of these diseases and is indicative of the pathogenesis of acne. Congenital adrenal hyperplasia (CAH) and seborrhoea-acne-hirsutism-androgenetic alopecia (SAHA) syndrome highlight the role of androgen steroids, while polycystic ovary (PCO) and hyperandrogenism-insulin resistance-acanthosis nigricans (HAIR-AN) syndromes indicate insulin resistance in acne. Apert syndrome with increased fibroblast growth factor receptor 2 (FGFR2) signalling results in follicular hyperkeratinization and sebaceous gland hypertrophy in acne. Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) and pyogenic arthritis-pyoderma gangrenosum-acne (PAPA) syndromes highlight the attributes of inflammation to acne formation. Advances in the understanding of the manifestation and molecular mechanisms of these syndromes will help to clarify acne pathogenesis and develop novel therapeutic modalities.

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ER -

Acne-associated syndromes: Models for better understanding of acne pathogenesis

Abstract

Keywords

UN SDGs

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