Accelerated liver water T1 mapping using single-shot continuous inversion-recovery spiral imaging

Elizabeth Huaroc Moquillaza, Kilian Weiss, Jonathan Stelter, Lisa Steinhelfer, Yoo Jin Lee, Thomas Amthor, Peter Koken, Marcus R. Makowski, Rickmer Braren, Mariya Doneva, Dimitrios C. Karampinos

Research output: Contribution to journalArticlepeer-review


Purpose: Liver T1 mapping techniques typically require long breath holds or long scan time in free-breathing, need correction for (Formula presented.) inhomogeneities and process composite (water and fat) signals. The purpose of this work is to accelerate the multi-slice acquisition of liver water selective T1 (wT1) mapping in a single breath hold, improving the k-space sampling efficiency. Methods: The proposed continuous inversion-recovery (IR) Look-Locker methodology combines a single-shot gradient echo spiral readout, Dixon processing and a dictionary-based analysis for liver wT1 mapping at 3 T. The sequence parameters were adapted to obtain short scan times. The influence of fat, (Formula presented.) inhomogeneities and TE on the estimation of T1 was first assessed using simulations. The proposed method was then validated in a phantom and in 10 volunteers, comparing it with MRS and the modified Look-Locker inversion-recovery (MOLLI) method. Finally, the clinical feasibility was investigated by comparing wT1 maps with clinical scans in nine patients. Results: The phantom results are in good agreement with MRS. The proposed method encodes the IR-curve for the liver wT1 estimation, is minimally sensitive to (Formula presented.) inhomogeneities and acquires one slice in 1.2 s. The volunteer results confirmed the multi-slice capability of the proposed method, acquiring nine slices in a breath hold of 11 s. The present work shows robustness to (Formula presented.) inhomogeneities ((Formula presented.), good repeatability ((Formula presented.) and is in better agreement with MRS ((Formula presented.) than is MOLLI ((Formula presented.). The wT1 maps in patients captured diverse lesions, thus showing their clinical feasibility. Conclusion: A single-shot spiral acquisition can be combined with a continuous IR Look-Locker method to perform rapid repeatable multi-slice liver water T1 mapping at a rate of 1.2 s per slice without a (Formula presented.) map. The proposed method is suitable for nine-slice liver clinical applications acquired in a single breath hold of 11 s.

Original languageEnglish
Article numbere5097
JournalNMR in Biomedicine
Issue number5
StatePublished - May 2024
Externally publishedYes


  • Look-Locker method
  • dictionary matching
  • liver water T mapping
  • spiral trajectory
  • water-fat separation


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