Accelerated aging of the putamen in men but not in women

Sabine Nunnemann; Afra M. Wohlschläger; Rüdiger Ilg; Christian Gaser; Thorleif Etgen; Bastian Conrad; Claus Zimmer; Mark Mühlau

doi:10.1016/j.neurobiolaging.2007.05.016

Accelerated aging of the putamen in men but not in women

Sabine Nunnemann, Afra M. Wohlschläger, Rüdiger Ilg, Christian Gaser, Thorleif Etgen, Bastian Conrad, Claus Zimmer, Mark Mühlau

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Age-related structural brain changes have been demonstrated repeatedly but data on the effect of gender on age-related structural brain changes are conflicting. Using high-resolution T1-weighted magnetic resonance imaging and voxel-based morphometry, we examined a population of 133 healthy adults (women, 73; men, 60; age range, 29-80 years) focusing on differential aging between men and women (i.e., interaction of age and gender). Compared to women, men showed accelerated age-related gray matter (GM) loss in the posterior putamen. Our data may constitute the structural substrate for age-related differences in motor function between men and women such as the higher incidence and earlier onset of Parkinson's disease in men.

Original language	English
Pages (from-to)	147-151
Number of pages	5
Journal	Neurobiology of Aging
Volume	30
Issue number	1
DOIs	https://doi.org/10.1016/j.neurobiolaging.2007.05.016
State	Published - Jan 2009

Keywords

Aging
Gender
Putamen
Voxel-based morphometry

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10.1016/j.neurobiolaging.2007.05.016

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title = "Accelerated aging of the putamen in men but not in women",

abstract = "Age-related structural brain changes have been demonstrated repeatedly but data on the effect of gender on age-related structural brain changes are conflicting. Using high-resolution T1-weighted magnetic resonance imaging and voxel-based morphometry, we examined a population of 133 healthy adults (women, 73; men, 60; age range, 29-80 years) focusing on differential aging between men and women (i.e., interaction of age and gender). Compared to women, men showed accelerated age-related gray matter (GM) loss in the posterior putamen. Our data may constitute the structural substrate for age-related differences in motor function between men and women such as the higher incidence and earlier onset of Parkinson's disease in men.",

keywords = "Aging, Gender, Putamen, Voxel-based morphometry",

author = "Sabine Nunnemann and Wohlschl{\"a}ger, {Afra M.} and R{\"u}diger Ilg and Christian Gaser and Thorleif Etgen and Bastian Conrad and Claus Zimmer and Mark M{\"u}hlau",

note = "Funding Information: S. Nunnemann and her colleagues from the Department of Neurology (Technische Universit{\"a}t M{\"u}nchen) were supported by Fond 766160 of the “Kommission f{\"u}r Klinische Forschung (KKF), Klinikum rechts der Isar, Technische Universit{\"a}t M{\"u}nchen”. ",

year = "2009",

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doi = "10.1016/j.neurobiolaging.2007.05.016",

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AU - Nunnemann, Sabine

AU - Wohlschläger, Afra M.

AU - Ilg, Rüdiger

AU - Gaser, Christian

AU - Etgen, Thorleif

AU - Conrad, Bastian

AU - Zimmer, Claus

AU - Mühlau, Mark

N1 - Funding Information: S. Nunnemann and her colleagues from the Department of Neurology (Technische Universität München) were supported by Fond 766160 of the “Kommission für Klinische Forschung (KKF), Klinikum rechts der Isar, Technische Universität München”.

PY - 2009/1

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N2 - Age-related structural brain changes have been demonstrated repeatedly but data on the effect of gender on age-related structural brain changes are conflicting. Using high-resolution T1-weighted magnetic resonance imaging and voxel-based morphometry, we examined a population of 133 healthy adults (women, 73; men, 60; age range, 29-80 years) focusing on differential aging between men and women (i.e., interaction of age and gender). Compared to women, men showed accelerated age-related gray matter (GM) loss in the posterior putamen. Our data may constitute the structural substrate for age-related differences in motor function between men and women such as the higher incidence and earlier onset of Parkinson's disease in men.

AB - Age-related structural brain changes have been demonstrated repeatedly but data on the effect of gender on age-related structural brain changes are conflicting. Using high-resolution T1-weighted magnetic resonance imaging and voxel-based morphometry, we examined a population of 133 healthy adults (women, 73; men, 60; age range, 29-80 years) focusing on differential aging between men and women (i.e., interaction of age and gender). Compared to women, men showed accelerated age-related gray matter (GM) loss in the posterior putamen. Our data may constitute the structural substrate for age-related differences in motor function between men and women such as the higher incidence and earlier onset of Parkinson's disease in men.

KW - Aging

KW - Gender

KW - Putamen

KW - Voxel-based morphometry

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ER -

Accelerated aging of the putamen in men but not in women

Abstract

Keywords

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