ABPP methodology: Introduction and overview

Matthew B. Nodwell, Stephan A. Sieber

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

27 Scopus citations


Activity-based protein profiling (ABPP) is emerging as a mature method for chemically interrogating the proteome of a cell. This chapter serves to introduce the reader to ABPP by providing overviews of the general principles of the technique, analytical methods used in ABPP, the classes of enzymes that can be specifically addressed by ABPP probes, and biological applications of ABPP.

Original languageEnglish
Title of host publicationActivity-Based Protein Profiling
EditorsStephan Sieber
Number of pages41
StatePublished - 2012

Publication series

NameTopics in Current Chemistry
ISSN (Print)0340-1022


  • Activity-based protein profiling
  • Analytical chemistry
  • Chemical biology
  • Proteomics


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