ABPP methodology: Introduction and overview

Matthew B. Nodwell, Stephan A. Sieber

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

27 Scopus citations

Abstract

Activity-based protein profiling (ABPP) is emerging as a mature method for chemically interrogating the proteome of a cell. This chapter serves to introduce the reader to ABPP by providing overviews of the general principles of the technique, analytical methods used in ABPP, the classes of enzymes that can be specifically addressed by ABPP probes, and biological applications of ABPP.

Original languageEnglish
Title of host publicationActivity-Based Protein Profiling
EditorsStephan Sieber
Pages1-41
Number of pages41
DOIs
StatePublished - 2012

Publication series

NameTopics in Current Chemistry
Volume324
ISSN (Print)0340-1022

Keywords

  • Activity-based protein profiling
  • Analytical chemistry
  • Chemical biology
  • Proteomics

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