ABO locus O¹ allele and risk of myocardial infarction

An association between ABO blood group and myocardial infarction (MI) has been described. One probable mechanism underlying this association is the influence of ABO blood group on plasma von Willebrand factor (vWF) levels. We conducted this genetic study to test whether the ABO O¹ allele is associated with low vWF plasma levels and with a reduced risk of MI. Cases consisted of 793 consecutive, angiographically examined patients with either acute or prior MI. As controls served 340 angiographically examined patients with neither coronary artery disease nor signs of MI. ABO locus alleles (A ¹, A², B, O¹, O²) were identified with polymerase chain reaction and fluorogenic probes. The distribution of O¹ alleles in the MI group versus the control group was: no O ¹ allele (15.4%/ 10.0%), one O¹ allele (49.7%/50.0%) and two O¹ alleles (34.9%/40.0%) (P = 0.035). O¹ allele carriage was associated with a 39% reduction in the risk of MI unadjusted odds ratio, 0.61; 95% confidence interval, 0.41-0.91). The significant association was maintained after adjustment for other cardiovascular risk factors. vWF antigen levels correlated with the number of O¹ alleles (P = 0.00003) in a separate control group (n = 164). Carriage of the O¹ allele is associated with a decreased risk of myocardial infarction, with homozygosity providing the greatest protection.