AAV-Mediated Expression of Dominant-Negative ULK1 Increases Neuronal Survival and Enhances Motor Performance in the MPTP Mouse Model of Parkinson’s Disease

Keyphrases

• 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 100%
• Adeno-associated Viral Vector 100%
• Autophagy 33%
• Autophagy Inhibition 16%
• Axonal Degeneration 33%
• Axonal Neurodegeneration 16%
• Bradykinesia 16%
• Disease Pathophysiology 16%
• Dominant Negative 100%
• Dopamine 16%
• Early Events 16%
• Immunohistochemical Analysis 16%
• Mammalian Target of Rapamycin (mTOR) 16%
• Motor Behavior 16%
• Motor Performance 100%
• Motor Symptoms 16%
• Mouse Model 100%
• Negative Type 16%
• Neuron Projection 16%
• Neuronal Survival 100%
• Neurotoxicity 16%
• Nigrostriatal Projection 33%
• Nigrostriatal System 16%
• Overexpression 16%
• Parkinson's Disease 33%
• Parkinson's Disease Model 100%
• Substantia Nigra 16%
• Tremor 16%
• ULK1 100%
• Western Blot Analysis 16%

Neuroscience

• Adeno Associated Virus Vector 100%
• Autophagy 50%
• Axonal Degeneration 33%
• Behavior (Neuroscience) 16%
• Bradykinesia 16%
• Dopaminergic 16%
• In Vivo 16%
• Kinase 16%
• mTOR Signaling 16%
• Nerve Fiber Degeneration 33%
• Neurodegeneration 16%
• Neurotoxicity 16%
• Parkinson's Disease 100%
• Substantia nigra 16%
• Tetrahydropyridine 100%
• Treatment of Parkinson's Disease 16%
• Tremor 16%
• Western Blot 16%