TY - JOUR
T1 - A Worm's Gut Feelings
T2 - Neuronal Muscarinic and Epithelial Canonical Wnt Pathways Promote Antimicrobial Defense
AU - Gerner, Romana R.
AU - Raffatellu, Manuela
N1 - Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2018/5/15
Y1 - 2018/5/15
N2 - Molecular mechanisms connecting the gut-brain axis to immunity remain elusive. In this issue of Immunity, Labed et al. (2018) demonstrate that two evolutionarily conserved signaling mechanisms, the neuronal muscarinic and the epithelial Wnt pathways, together induce antimicrobial peptide expression that protects Caenorhabditis elegans against intestinal infection. Molecular mechanisms connecting the gut-brain axis to immunity remain elusive. In this issue of Immunity, Labed et al. (2018) demonstrate that two evolutionarily conserved signaling mechanisms, the neuronal muscarinic and the epithelial Wnt pathways, together induce antimicrobial peptide expression that protects Caenorhabditis elegans against intestinal infection.
AB - Molecular mechanisms connecting the gut-brain axis to immunity remain elusive. In this issue of Immunity, Labed et al. (2018) demonstrate that two evolutionarily conserved signaling mechanisms, the neuronal muscarinic and the epithelial Wnt pathways, together induce antimicrobial peptide expression that protects Caenorhabditis elegans against intestinal infection. Molecular mechanisms connecting the gut-brain axis to immunity remain elusive. In this issue of Immunity, Labed et al. (2018) demonstrate that two evolutionarily conserved signaling mechanisms, the neuronal muscarinic and the epithelial Wnt pathways, together induce antimicrobial peptide expression that protects Caenorhabditis elegans against intestinal infection.
UR - http://www.scopus.com/inward/record.url?scp=85046724313&partnerID=8YFLogxK
U2 - 10.1016/j.immuni.2018.04.035
DO - 10.1016/j.immuni.2018.04.035
M3 - Short survey
C2 - 29768168
AN - SCOPUS:85046724313
SN - 1074-7613
VL - 48
SP - 839
EP - 841
JO - Immunity
JF - Immunity
IS - 5
ER -
