A three-state mechanism of integrin activation and signal transduction for integrin αvβ3

Kay E. Gottschalk; Robert Günther; Horst Kessler

doi:10.1002/1439-7633(20020503)3:5<470::AID-CBIC470>3.0.CO;2-X

A three-state mechanism of integrin activation and signal transduction for integrin α_vβ₃

Kay E. Gottschalk
, Robert Günther
, Horst Kessler

TUM Emeriti of Excellence

Technical University of Munich

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Calcium ion shifts appear to be important for integrin conformational changes in binding processes. Ligand binding and signal transduction of integrins are poorly understood. Here we present a three-state model of a signal transduction event (see figure) based on molecular modeling and docking studies of integrin α_vβ₃ that involves allosteric effects triggered by a ligand-induced shift of a Ca²⁺ ion.

Original language	English
Pages (from-to)	470-473
Number of pages	4
Journal	ChemBioChem
Volume	3
Issue number	5
DOIs	https://doi.org/10.1002/1439-7633(20020503)3:5<470::AID-CBIC470>3.0.CO;2-X
State	Published - 2002

Keywords

Docking
Drug research
Integrins
Molecular modeling
Signal transduction

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10.1002/1439-7633(20020503)3:5<470::AID-CBIC470>3.0.CO;2-X

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title = "A three-state mechanism of integrin activation and signal transduction for integrin αvβ3",

abstract = "Calcium ion shifts appear to be important for integrin conformational changes in binding processes. Ligand binding and signal transduction of integrins are poorly understood. Here we present a three-state model of a signal transduction event (see figure) based on molecular modeling and docking studies of integrin αvβ3 that involves allosteric effects triggered by a ligand-induced shift of a Ca2+ ion.",

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AU - Gottschalk, Kay E.

AU - Günther, Robert

AU - Kessler, Horst

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Y1 - 2002

N2 - Calcium ion shifts appear to be important for integrin conformational changes in binding processes. Ligand binding and signal transduction of integrins are poorly understood. Here we present a three-state model of a signal transduction event (see figure) based on molecular modeling and docking studies of integrin αvβ3 that involves allosteric effects triggered by a ligand-induced shift of a Ca2+ ion.

AB - Calcium ion shifts appear to be important for integrin conformational changes in binding processes. Ligand binding and signal transduction of integrins are poorly understood. Here we present a three-state model of a signal transduction event (see figure) based on molecular modeling and docking studies of integrin αvβ3 that involves allosteric effects triggered by a ligand-induced shift of a Ca2+ ion.

KW - Docking

KW - Drug research

KW - Integrins

KW - Molecular modeling

KW - Signal transduction

UR - https://www.scopus.com/pages/publications/0036903735

U2 - 10.1002/1439-7633(20020503)3:5<470::AID-CBIC470>3.0.CO;2-X

DO - 10.1002/1439-7633(20020503)3:5<470::AID-CBIC470>3.0.CO;2-X

M3 - Article

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AN - SCOPUS:0036903735

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SP - 470

EP - 473

JO - ChemBioChem

JF - ChemBioChem

IS - 5

ER -

A three-state mechanism of integrin activation and signal transduction for integrin α_vβ₃

Abstract

Keywords

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