TY - JOUR
T1 - A surface plasmon resonance biochip that operates both in the angular and wavelength interrogation modes
AU - Oliveira, Leiva Casemiro
AU - Moreira, Cleumar Da Silva
AU - Thirstrup, Carsten
AU - Melcher, Elmar Uwe Kurt
AU - Lima, Antonio Marcus Nogueira
AU - Neff, Helmut
PY - 2013
Y1 - 2013
N2 - This paper presents a surface plasmon resonance system based on a polymer prism chip. The device allows operation in both the angular and wavelength interrogation modes. The biochip design is discussed emphasizing the effect of the ambient temperature over the optical behavior. Birefringence effect, biochip polishing, and responsivity are also reported. The basic mathematical formulation for both operating modes is discussed, and morphological parameters are considered in the data analysis. Experimental sensorgrams obtained at both interrogation modes with the same polymer prism chip are presented and compared. The experimental sensorgrams obtained with assays providing reversible (phosphate buffered saline and hypochlorite solutions) and irreversible (neutravindin solution) bindings demonstrate the feasibility of the proposed design.
AB - This paper presents a surface plasmon resonance system based on a polymer prism chip. The device allows operation in both the angular and wavelength interrogation modes. The biochip design is discussed emphasizing the effect of the ambient temperature over the optical behavior. Birefringence effect, biochip polishing, and responsivity are also reported. The basic mathematical formulation for both operating modes is discussed, and morphological parameters are considered in the data analysis. Experimental sensorgrams obtained at both interrogation modes with the same polymer prism chip are presented and compared. The experimental sensorgrams obtained with assays providing reversible (phosphate buffered saline and hypochlorite solutions) and irreversible (neutravindin solution) bindings demonstrate the feasibility of the proposed design.
KW - Biomedical transducers
KW - optical spectroscopy
KW - optical transducers
KW - optoelectronic devices
KW - plasmons
KW - thin-film devices
UR - http://www.scopus.com/inward/record.url?scp=84876047027&partnerID=8YFLogxK
U2 - 10.1109/TIM.2012.2232433
DO - 10.1109/TIM.2012.2232433
M3 - Article
AN - SCOPUS:84876047027
SN - 0018-9456
VL - 62
SP - 1223
EP - 1232
JO - IEEE Transactions on Instrumentation and Measurement
JF - IEEE Transactions on Instrumentation and Measurement
IS - 5
M1 - 6408117
ER -