A Sugar Amino Acid as a Novel Peptidomimetic

Erich Graf von Roedern, Horst Kessler

Research output: Contribution to journalArticlepeer-review

129 Scopus citations

Abstract

A sugar amino acid in the peptide backbone marks a novel class of unnatural peptide building blocks with interesting properties. By incorporation of the readily accessible sugar amino acid into peptides, the structure and pharmacokinetics can be influenced directly. This is demonstrated for cyclic and linear somatostatin (1) and enkephalin analogues. (Figure Presented.)

Original languageEnglish
Pages (from-to)687-689
Number of pages3
JournalAngewandte Chemie International Edition in English
Volume33
Issue number6
DOIs
StatePublished - 31 Mar 1994

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