A state-of-the-art cyanation of aryl bromides: A novel and versatile copper catalyst system inspired by nature

Thomas Schareina, Alexander Zapf, Wolfgang Mägerlein, Nikolaus Müller, Matthias Beller

Research output: Contribution to journalArticlepeer-review

134 Scopus citations

Abstract

A general protocol for the cyanation of aryl halides with the nontoxic cyanide source K4[Fe(CN)6] using copper catalysis and a ligand system based on 1-alkylimidazoles is presented. The advantages of this system are the high selectivity, a unique substrate range, easy handling, and inexpensive reagents.

Original languageEnglish
Pages (from-to)6249-6254
Number of pages6
JournalChemistry - A European Journal
Volume13
Issue number21
DOIs
StatePublished - 2007
Externally publishedYes

Keywords

  • Alkylimidazoles
  • Bromoarenes
  • Copper
  • Cyanation
  • Nitriles

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