A small-molecule antagonist of the Hedgehog signaling pathway

Jongkook Lee; Xu Wu; Marina Pasca Di Magliano; Eric C. Peters; Yan Wang; Jiyong Hong; Metthias Hebrok; Sheng Ding; Charles Y. Cho; Peter G. Schultz

doi:10.1002/cbic.200700403

A small-molecule antagonist of the Hedgehog signaling pathway

Jongkook Lee, Xu Wu, Marina Pasca Di Magliano, Eric C. Peters, Yan Wang, Jiyong Hong, Metthias Hebrok, Sheng Ding, Charles Y. Cho, Peter G. Schultz

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Abstract

(Chemical Equation Presented) Shadow the Hedgehog. JK184 (illustrated in the scheme) was identified as an antagonist of Hedgehog signaling through a cell-based screen of chemical libraries. Results from biochemical and cellular experiments suggest that JK184 functions by inhibiting class IV alcohol dehydrogenase. This molecule should serve as a useful tool for studying Hedgehog signaling.

Original language	English
Pages (from-to)	1916-1919
Number of pages	4
Journal	ChemBioChem
Volume	8
Issue number	16
DOIs	https://doi.org/10.1002/cbic.200700403
State	Published - 5 Nov 2007
Externally published	Yes

Keywords

Alcohol dehydrogenase 7
Hedgehog signaling
Inhibitors
Signal transduction

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10.1002/cbic.200700403

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AU - Wu, Xu

AU - Di Magliano, Marina Pasca

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AU - Hong, Jiyong

AU - Hebrok, Metthias

AU - Ding, Sheng

AU - Cho, Charles Y.

AU - Schultz, Peter G.

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KW - Alcohol dehydrogenase 7

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KW - Inhibitors

KW - Signal transduction

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A small-molecule antagonist of the Hedgehog signaling pathway

Abstract

Keywords

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