A singular value based probability algorithm for protein cleavage

T. Stolte; P. Rentrop

doi:10.1007/978-3-540-74238-8_9

A singular value based probability algorithm for protein cleavage

T. Stolte, P. Rentrop

Chair of Automotive Technology

Technical University of Munich

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Protein degradation by the proteasome is one of the key steps in cell biology and in immune biology. For degradation a mathematical model can be based on a binomial distribution, where the wanted cleavage probabilities are characterized by a minimization problem. The proposed method analyzes the singular values of the Jacobian, thus giving a significant parameter reduction. The computation time is 50 fold reduced compared to the unreduced model, which in practice means hours instead of days for a run. The implementation is based on MATLAB.

Original language	English
Title of host publication	From Nano to Space
Subtitle of host publication	Applied Mathematics Inspired by Roland Bulirsch
Publisher	Springer Berlin Heidelberg
Pages	99-110
Number of pages	12
ISBN (Print)	9783540742371
DOIs	https://doi.org/10.1007/978-3-540-74238-8_9
State	Published - 2008

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10.1007/978-3-540-74238-8_9

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abstract = "Protein degradation by the proteasome is one of the key steps in cell biology and in immune biology. For degradation a mathematical model can be based on a binomial distribution, where the wanted cleavage probabilities are characterized by a minimization problem. The proposed method analyzes the singular values of the Jacobian, thus giving a significant parameter reduction. The computation time is 50 fold reduced compared to the unreduced model, which in practice means hours instead of days for a run. The implementation is based on MATLAB.",

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A singular value based probability algorithm for protein cleavage

Abstract

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