A self-assembled delivery platform with post-production tunable release rate

Job Boekhoven, Mathijs Koot, Tim A. Wezendonk, Rienk Eelkema, Jan H. Van Esch

Research output: Contribution to journalArticlepeer-review

89 Scopus citations

Abstract

Self-assembly of three molecular components results in a delivery platform, the release rate of which can be tuned after its production. A fluorophore-conjugated gelator can be hydrolyzed by an enzyme, resulting in the release of a fluorescent small molecule. To allow the release to be tunable, the enzyme is entrapped in liposomes and can be liberated by heating the system for a short period. Crucially, the heating time determines the amount of enzyme liberated; with that, the release rate can be tuned by the time of heating.

Original languageEnglish
Pages (from-to)12908-12911
Number of pages4
JournalJournal of the American Chemical Society
Volume134
Issue number31
DOIs
StatePublished - 8 Aug 2012
Externally publishedYes

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