A secreted enzyme reporter system for MRI

Gil G. Westmeyer, Yves Durocher, Alan Jasanoff

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

(Figure Presented) Let's see what comes out: An extracellular enzymatic gene-reporter system for magnetic resonance imaging (MRI) yields strong, reversible contrast changes in response to the expression of secreted alkaline phosphatase (SEAP; see picture). Products of SEAP activity were specifically detected using an iron-oxide-based sensor. The contrast agent is not used up by the enzyme, cell delivery is not required, and multimodal detection is possible.

Original languageEnglish
Pages (from-to)3909-3911
Number of pages3
JournalAngewandte Chemie International Edition in English
Volume49
Issue number23
DOIs
StatePublished - 25 May 2010
Externally publishedYes

Keywords

  • Alkaline phosphatase
  • Aptamers
  • Enzymatic reporters
  • Gene reporters
  • Magnetic resonance imaging

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