TY - JOUR
T1 - A role for glia in cellular and systemic metabolism
T2 - insights from the fly
AU - De Backer, Jean François
AU - Grunwald Kadow, Ilona C.
N1 - Publisher Copyright:
© 2022 The Authors
PY - 2022/10
Y1 - 2022/10
N2 - Excitability and synaptic transmission make neurons high-energy consumers. However, neurons do not store carbohydrates or lipids. Instead, they need support cells to fuel their metabolic demands. This role is assumed by glia, both in vertebrates and invertebrates. Many questions remain regarding the coupling between neuronal activity and energy demand on the one hand, and nutrient supply by glia on the other hand. Here, we review recent advances showing that fly glia, similar to their role in vertebrates, fuel neurons in times of high energetic demand, such as during memory formation and long-term storage. Vertebrate glia also play a role in the modulation of neurons, their communication, and behavior, including food search and feeding. We discuss recent literature pointing to similar roles of fly glia in behavior and metabolism.
AB - Excitability and synaptic transmission make neurons high-energy consumers. However, neurons do not store carbohydrates or lipids. Instead, they need support cells to fuel their metabolic demands. This role is assumed by glia, both in vertebrates and invertebrates. Many questions remain regarding the coupling between neuronal activity and energy demand on the one hand, and nutrient supply by glia on the other hand. Here, we review recent advances showing that fly glia, similar to their role in vertebrates, fuel neurons in times of high energetic demand, such as during memory formation and long-term storage. Vertebrate glia also play a role in the modulation of neurons, their communication, and behavior, including food search and feeding. We discuss recent literature pointing to similar roles of fly glia in behavior and metabolism.
UR - http://www.scopus.com/inward/record.url?scp=85134827667&partnerID=8YFLogxK
U2 - 10.1016/j.cois.2022.100947
DO - 10.1016/j.cois.2022.100947
M3 - Review article
C2 - 35772690
AN - SCOPUS:85134827667
SN - 2214-5745
VL - 53
JO - Current Opinion in Insect Science
JF - Current Opinion in Insect Science
M1 - 100947
ER -