A role for glia in cellular and systemic metabolism: insights from the fly

Jean François De Backer, Ilona C. Grunwald Kadow

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Excitability and synaptic transmission make neurons high-energy consumers. However, neurons do not store carbohydrates or lipids. Instead, they need support cells to fuel their metabolic demands. This role is assumed by glia, both in vertebrates and invertebrates. Many questions remain regarding the coupling between neuronal activity and energy demand on the one hand, and nutrient supply by glia on the other hand. Here, we review recent advances showing that fly glia, similar to their role in vertebrates, fuel neurons in times of high energetic demand, such as during memory formation and long-term storage. Vertebrate glia also play a role in the modulation of neurons, their communication, and behavior, including food search and feeding. We discuss recent literature pointing to similar roles of fly glia in behavior and metabolism.

Original languageEnglish
Article number100947
JournalCurrent Opinion in Insect Science
Volume53
DOIs
StatePublished - Oct 2022

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