TY - GEN
T1 - A reduced stoichiometric model to describe metabolism in hepatocytes
AU - Kremling, Andreas
AU - Zeilinger, Katrin
AU - Gerlach, Jörg C.
AU - Gilles, Ernst Dieter
PY - 2007
Y1 - 2007
N2 - Stoichiometric models are widely used in Metabolic Engineering and Systems Biology to estimate the flux distribution in cellular systems during steady-state operation. For a number of applications it is desirable to have a model with a small number of state variables. This is of particular interest, if static metabolic models are combined with dynamical models of gene expression. Such integrated models can be used to analyze, monitor and control cell culture bioreactors working as extracorporeal liver support systems. Such systems provide the option for bridging the liver function in case of acute hepatic failure until liver transplantation or until regeneration of the patient's own organ. In this contribution a reduced stoichiometric model of the central metabolism of hepatocytes, i.e. the most important cell type in the liver, is presented.
AB - Stoichiometric models are widely used in Metabolic Engineering and Systems Biology to estimate the flux distribution in cellular systems during steady-state operation. For a number of applications it is desirable to have a model with a small number of state variables. This is of particular interest, if static metabolic models are combined with dynamical models of gene expression. Such integrated models can be used to analyze, monitor and control cell culture bioreactors working as extracorporeal liver support systems. Such systems provide the option for bridging the liver function in case of acute hepatic failure until liver transplantation or until regeneration of the patient's own organ. In this contribution a reduced stoichiometric model of the central metabolism of hepatocytes, i.e. the most important cell type in the liver, is presented.
UR - http://www.scopus.com/inward/record.url?scp=43049170011&partnerID=8YFLogxK
U2 - 10.1109/CCA.2006.286133
DO - 10.1109/CCA.2006.286133
M3 - Conference contribution
AN - SCOPUS:43049170011
SN - 0780397959
SN - 9780780397958
T3 - Proceedings of the IEEE International Conference on Control Applications
SP - 1725
EP - 1729
BT - Proceedings of the 2006 IEEE International Conference on Control Applications
T2 - Joint 2006 IEEE Conference on Control Applications (CCA), Computer-Aided Control Systems Design Symposium (CACSD) and International Symposium on Intelligent Control (ISIC)
Y2 - 4 October 2006 through 6 October 2006
ER -