A rare case of H3K27-altered diffuse midline glioma with multiple osseous and spinal metastases at the time of diagnosis

A. Kaywan Aftahy, Vicki M. Butenschoen, Lisa Hoenikl, Friederike Liesche-Starnecker, Benedikt Wiestler, Friederike Schmidt-Graf, Bernhard Meyer, Jens Gempt

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Background: H3K27-altered diffuse midline gliomas are uncommon central nervous system tumors with extremely poor prognoses. Case presentation: We report the case of a 24-year-old man patient with multiple, inter alia osseous metastases who presented with back pain, hemi-hypoesthesia, and hemi-hyperhidrosis. The patient underwent combined radio-chemotherapy and demonstrated temporary improvement before deteriorating. Conclusions: H3K27-altered diffuse midline glioma presents an infrequent but crucial differential diagnosis and should be considered in cases with rapid neurological deterioration and multiple intracranial and intramedullary tumor lesions in children and young adults. Combined radio-chemotherapy delayed the neurological deterioration, but unfortunately, progression occurred three months after the diagnosis.

Original languageEnglish
Article number87
JournalBMC Neurology
Volume23
Issue number1
DOIs
StatePublished - Dec 2023
Externally publishedYes

Keywords

  • Diffuse midline Glioma
  • Extraneural metastases
  • H3K27M
  • Neuro-oncology

Fingerprint

Dive into the research topics of 'A rare case of H3K27-altered diffuse midline glioma with multiple osseous and spinal metastases at the time of diagnosis'. Together they form a unique fingerprint.

Cite this