A prospective study of serum ghrelin levels in patients treated with clozapine

F. M. Theisen; S. Gebhardt; T. Brömel; B. Otto; W. Heldwein; M. Heinzel-Gutenbrunner; J. C. Krieg; H. Remschmidt; M. Tschöp; J. Hebebrand

doi:10.1007/s00702-005-0284-6

A prospective study of serum ghrelin levels in patients treated with clozapine

F. M. Theisen, S. Gebhardt, T. Brömel, B. Otto, W. Heldwein, M. Heinzel-Gutenbrunner, J. C. Krieg, H. Remschmidt, M. Tschöp, J. Hebebrand

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42 Scopus citations

Abstract

We investigated serum ghrelin levels (SGL) in 12 patients with schizophrenia over a 10-week period after initiation of clozapine treatment. In contrast to increments of body mass indices (BMI, kg/m ²) and serum leptin levels (SLL), no significant change in SGL was detected. Inverse correlations between delta SGL and delta SLL did not reach statistical significance. Linear mixed model analysis could not detect effects of age, sex, BMI, SLL and serum clozapine levels on SGL. Our results do not support a causal involvement of ghrelin in clozapine-related weight gain.

Original language	English
Pages (from-to)	1411-1416
Number of pages	6
Journal	Journal of Neural Transmission
Volume	112
Issue number	10
DOIs	https://doi.org/10.1007/s00702-005-0284-6
State	Published - Oct 2005
Externally published	Yes

Keywords

Antipsychotics
Body mass index
Leptin
Neuroleptics
Weight gain

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00702-005-0284-6

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abstract = "We investigated serum ghrelin levels (SGL) in 12 patients with schizophrenia over a 10-week period after initiation of clozapine treatment. In contrast to increments of body mass indices (BMI, kg/m 2) and serum leptin levels (SLL), no significant change in SGL was detected. Inverse correlations between delta SGL and delta SLL did not reach statistical significance. Linear mixed model analysis could not detect effects of age, sex, BMI, SLL and serum clozapine levels on SGL. Our results do not support a causal involvement of ghrelin in clozapine-related weight gain.",

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AU - Theisen, F. M.

AU - Gebhardt, S.

AU - Brömel, T.

AU - Otto, B.

AU - Heldwein, W.

AU - Heinzel-Gutenbrunner, M.

AU - Krieg, J. C.

AU - Remschmidt, H.

AU - Tschöp, M.

AU - Hebebrand, J.

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N2 - We investigated serum ghrelin levels (SGL) in 12 patients with schizophrenia over a 10-week period after initiation of clozapine treatment. In contrast to increments of body mass indices (BMI, kg/m 2) and serum leptin levels (SLL), no significant change in SGL was detected. Inverse correlations between delta SGL and delta SLL did not reach statistical significance. Linear mixed model analysis could not detect effects of age, sex, BMI, SLL and serum clozapine levels on SGL. Our results do not support a causal involvement of ghrelin in clozapine-related weight gain.

AB - We investigated serum ghrelin levels (SGL) in 12 patients with schizophrenia over a 10-week period after initiation of clozapine treatment. In contrast to increments of body mass indices (BMI, kg/m 2) and serum leptin levels (SLL), no significant change in SGL was detected. Inverse correlations between delta SGL and delta SLL did not reach statistical significance. Linear mixed model analysis could not detect effects of age, sex, BMI, SLL and serum clozapine levels on SGL. Our results do not support a causal involvement of ghrelin in clozapine-related weight gain.

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A prospective study of serum ghrelin levels in patients treated with clozapine

Abstract

Keywords

UN SDGs

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