A practical and benign synthesis of primary amines through ruthenium-catalyzed reduction of nitriles.

Stephan Enthaler, Kathrin Junge, Daniele Addis, Giulia Erre, Matthias Beller

Research output: Contribution to journalArticlepeer-review

99 Scopus citations

Abstract

The catalytic hydrogenation of nitriles represents an atom-economic and valuable route to amines. In the present study, the ruthenium-catalyzed hydrogenation of various organic nitriles to give primary amines has been examined in detail. Straightforward ruthenium complexes modified by cheap and widely available triphenylphosphine allow for the efficient and general reduction of various aryl, alkyl, and heterocyclic nitriles. By using a practical in situ catalyst composed of [Ru(cod)(methylallyl(2))] and PPh(3), excellent yields and chemoselectivity were achieved. Moreover, the catalyst system displays broad functional group tolerance.

Original languageEnglish
Pages (from-to)1006-1010
Number of pages5
JournalChemSusChem
Volume1
Issue number12
DOIs
StatePublished - 2008
Externally publishedYes

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