A photolabile linker for the mild and selective cleavage of enriched biomolecules from solid support

Ronald Orth, Stephan A. Sieber

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

(Chemical Equation Presented) Selective release of enriched biomolecules from solid support is a desirable goal in proteomic and metabolomic studies. Here we demonstrate that photocleavage of a light-sensitive phenacyl ester bond is a suitable alternative cleavage strategy for the selective release of enriched biomolecules form avidin beads circumventing the disadvantages of conventional heat denaturation procedures.

Original languageEnglish
Pages (from-to)8476-8479
Number of pages4
JournalJournal of Organic Chemistry
Volume74
Issue number21
DOIs
StatePublished - 6 Nov 2009
Externally publishedYes

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