A Pd-labile fluoroquinolone prodrug efficiently prevents biofilm formation on coated surfaces

Josef Braun; M. Carmen Ortega-Liebana; Asier Unciti-Broceta; Stephan A. Sieber

doi:10.1039/d4ob00014e

A Pd-labile fluoroquinolone prodrug efficiently prevents biofilm formation on coated surfaces

Josef Braun, M. Carmen Ortega-Liebana, Asier Unciti-Broceta, Stephan A. Sieber

Chair of Organic Chemistry II

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Surface-adhered bacteria on implants represent a major challenge for antibiotic treatment. We introduce hydrogel-coated surfaces loaded with tailored Pd-nanosheets which catalyze the release of antibiotics from inactive prodrugs. Masked and antibiotically inactive fluoroquinolone analogs were efficiently activated at the surface and prevented the formation of Staphylococcus aureus biofilms.

Original language	English
Pages (from-to)	1998-2002
Number of pages	5
Journal	Organic and Biomolecular Chemistry
Volume	22
Issue number	10
DOIs	https://doi.org/10.1039/d4ob00014e
State	Published - 7 Feb 2024

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10.1039/d4ob00014e

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abstract = "Surface-adhered bacteria on implants represent a major challenge for antibiotic treatment. We introduce hydrogel-coated surfaces loaded with tailored Pd-nanosheets which catalyze the release of antibiotics from inactive prodrugs. Masked and antibiotically inactive fluoroquinolone analogs were efficiently activated at the surface and prevented the formation of Staphylococcus aureus biofilms.",

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AU - Ortega-Liebana, M. Carmen

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AU - Sieber, Stephan A.

PY - 2024/2/7

Y1 - 2024/2/7

N2 - Surface-adhered bacteria on implants represent a major challenge for antibiotic treatment. We introduce hydrogel-coated surfaces loaded with tailored Pd-nanosheets which catalyze the release of antibiotics from inactive prodrugs. Masked and antibiotically inactive fluoroquinolone analogs were efficiently activated at the surface and prevented the formation of Staphylococcus aureus biofilms.

AB - Surface-adhered bacteria on implants represent a major challenge for antibiotic treatment. We introduce hydrogel-coated surfaces loaded with tailored Pd-nanosheets which catalyze the release of antibiotics from inactive prodrugs. Masked and antibiotically inactive fluoroquinolone analogs were efficiently activated at the surface and prevented the formation of Staphylococcus aureus biofilms.

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EP - 2002

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

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ER -

A Pd-labile fluoroquinolone prodrug efficiently prevents biofilm formation on coated surfaces

Abstract

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