A novel family of human leukocyte antigen class II receptors may have its origin in archaic human species

Sebastian Temme, Martin Zacharias, Jürgen Neumann, Sebastian Wohlfromm, Angelika König, Nadine Temme, Sebastian Springer, John Trowsdale, Norbert Koch

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Background: How are isotype-mixed HLA class II heterodimers selected from the large pool of α-β subunit combinations? Results: Two critical sequences in DPΒ and the chaperone invariant chain control assembly of isotype-mixed HLA-DRαDPβ heterodimers. Conclusion: A substantial proportion of HLA-DPβ allotypes, with the DPβ motif Lys-69/GGPM-(84-87), form matched heterodimers with DRα.

Original languageEnglish
Pages (from-to)639-653
Number of pages15
JournalJournal of Biological Chemistry
Volume289
Issue number2
DOIs
StatePublished - 10 Jan 2014
Externally publishedYes

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