A novel domino synthesis of quinazolinediones by palladium-catalyzed double carbonylation

Haoquan Li, Wanfang Li, Anke Spannenberg, Wolfgang Baumann, Helfried Neumann, Matthias Beller, Xiao Feng Wu

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

Combining commercially available bromoanilines and bromobenzonitriles in a novel double carbonylation process allows for a straightforward synthesis of isoindolo[1,2-b]quinazoline-10,12-diones. At least five different C-C and/or C-N bonds are selectively formed in this 3-component reaction, which likely proceeds through sequential carbonylation-cyclization-isomerisation- carbonylation steps. Notably, two molecules of CO are inserted in this highly efficient palladium-catalyzed process.

Original languageEnglish
Pages (from-to)8541-8544
Number of pages4
JournalChemistry - A European Journal
Volume20
Issue number28
DOIs
StatePublished - 7 Jul 2014
Externally publishedYes

Keywords

  • carbonylation
  • coupling
  • domino reactions
  • multicomponent reactions
  • palladium

Fingerprint

Dive into the research topics of 'A novel domino synthesis of quinazolinediones by palladium-catalyzed double carbonylation'. Together they form a unique fingerprint.

Cite this