A new palladium-catalyzed P-C coupling reaction: Synthesis of triarylphosphine oxides and diarylmethylphosphine oxides

Gene A. Stark, Thomas H. Riermeier, Matthias Beller

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

The first palladium-catalyzed P-C coupling reaction of aryl halides with (hydroxymethyl)phosphines is described. Hydroxymethylphosphines act as cheap and easy to use H3PO and CH3P(O)H2 equivalents. Tertiary diarylmethylphosphine oxides 5 and triarylphosphine oxides 6 are accessible in a one pot reaction in overall yields between 45-60%.

Original languageEnglish
Pages (from-to)1703-1711
Number of pages9
JournalSynthetic Communications
Volume30
Issue number10
DOIs
StatePublished - 2000
Externally publishedYes

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