A new palladium catalyst system for the cyanation of aryl chlorides

Mark Sundermeier, Alexander Zapf, Matthias Beller, Jürgen Sans

Research output: Contribution to journalArticlepeer-review

148 Scopus citations

Abstract

The influence of reaction conditions and additives on the palladium-catalyzed cyanation of aryl chlorides with potassium cyanide has been investigated. Successful cyanation of aryl chlorides is observed in the presence of palladium catalysts using potassium cyanide. It is shown that the combination of a 1,5-bis(diphenylphosphino)pentane ligand and the addition of N,N,N′,N′-tetramethylethylenediamine (TMEDA) as a co-catalyst are the key factors in obtaining the corresponding aryl nitriles with improved catalyst productivities and selectivities.

Original languageEnglish
Pages (from-to)6707-6710
Number of pages4
JournalTetrahedron Letters
Volume42
Issue number38
DOIs
StatePublished - 17 Sep 2001
Externally publishedYes

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