A new palladium catalyst system for the cyanation of aryl chlorides with K4[Fe(CN)6]

Thomas Schareina, Alexander Zapf, Wolfgang Mägerlein, Nikolaus Müller, Matthias Beller

Research output: Contribution to journalArticlepeer-review

151 Scopus citations

Abstract

The development of a novel Pd-catalyzed synthesis of (hetero)aromatic nitriles from the corresponding aryl chlorides and potassium hexacyanoferrate(II) is described. This novel protocol avoids the use of highly toxic alkali cyanides and proceeds in the presence of small amounts of palladium catalysts. High yields and selectivities of the corresponding aryl nitriles were achieved applying di(1-adamantyl)-1-butylphosphine (cataCXium® A) as the ligand.

Original languageEnglish
Pages (from-to)1087-1090
Number of pages4
JournalTetrahedron Letters
Volume48
Issue number7
DOIs
StatePublished - 12 Feb 2007
Externally publishedYes

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