TY - JOUR
T1 - A new class of drugs for BNCT? Borylated derivatives of ferrocenium compounds in animal experiments
AU - Weissfloch, L.
AU - Wagner, M.
AU - Probst, T.
AU - Senekowitsch-Schmidtke, R.
AU - Tempel, K.
AU - Molls, M.
N1 - Funding Information:
The authors would like to thank F. Jäkle, M. Hug, and P. Nielsson for their support of this work. Further on, they would like to gratefully thank the Bayerisches Staats-ministerium für Landesentwick-lung und Umweltfragen, München, the Deutsche Forschungsgemeinschaft (DFG), Bonn, the Pinguin Foundation granted by the Company Henkel KG a. AG, Düsseldorf, as well as by the Technische Univer-sität München, Germany, for their financial support.
PY - 2001
Y1 - 2001
N2 - A new class of drugs, borylated derivatives of ferrocenium compounds, which show a comparatively facile synthesis is investigated on their boron neutron capture accumulation. Investigations focused on the fast and effective testing of 12 ferrocene derivatives with tetracoordinated boron atoms, which should accumulate in rodent tumors. The macroscopic studies on time-dependent boron distributions and boron concentrations in mice were carried out by inductively coupled plasma-atomic emission spectrometry, inductively coupled plasma-mass spectrometry, and quantitative neutron capture radiography. The determination of boron concentrations after injection of 2b showed high boron contents in spleen, liver, kidneys, less in lung and muscle, and poor in integral blood, blood plasma, tumor, and brain. It is interesting to note that 2b penetrates the blood-brain barrier which may be advantageous in the treatment of astrocytomas and glioblastomas.
AB - A new class of drugs, borylated derivatives of ferrocenium compounds, which show a comparatively facile synthesis is investigated on their boron neutron capture accumulation. Investigations focused on the fast and effective testing of 12 ferrocene derivatives with tetracoordinated boron atoms, which should accumulate in rodent tumors. The macroscopic studies on time-dependent boron distributions and boron concentrations in mice were carried out by inductively coupled plasma-atomic emission spectrometry, inductively coupled plasma-mass spectrometry, and quantitative neutron capture radiography. The determination of boron concentrations after injection of 2b showed high boron contents in spleen, liver, kidneys, less in lung and muscle, and poor in integral blood, blood plasma, tumor, and brain. It is interesting to note that 2b penetrates the blood-brain barrier which may be advantageous in the treatment of astrocytomas and glioblastomas.
KW - Boron neutron capture therapy (BNCT)
KW - Cancer therapy
KW - Ferrocene
KW - Murine tumor models
KW - Neurological toxicity
UR - http://www.scopus.com/inward/record.url?scp=0035041197&partnerID=8YFLogxK
U2 - 10.1023/A:1016686321179
DO - 10.1023/A:1016686321179
M3 - Article
C2 - 11368274
AN - SCOPUS:0035041197
SN - 0966-0844
VL - 14
SP - 43
EP - 49
JO - BioMetals
JF - BioMetals
IS - 1
ER -
