A new class of catalysts with superior activity and selectivity for amidocarbonylation reactions

Matthias Beller, Markus Eckert, Frank Vollmüller

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

For the first time, a detailed investigation of the newly developed palladium (Pd)-catalyzed amidocarbonylation for the synthesis of various N-acyl amino acids is described. A screening of important parameters led to a highly efficient process with the active catalyst system PdBr2/LiBr/H2SO4. Based on our study of the influence of solvent, temperature, pressure, co-catalysts and substrates, we draw up a profile of the Pd-catalyzed amidocarbonylation and discuss the mechanism in detail. The successful employment of acetals and various aldehydes as starting materials demonstrates the synthetic potential of this atomeconomic process.

Original languageEnglish
Pages (from-to)23-33
Number of pages11
JournalJournal of Molecular Catalysis A: Chemical
Volume135
Issue number1
DOIs
StatePublished - 29 Sep 1998
Externally publishedYes

Keywords

  • Amidocarbonylation
  • Catalysis
  • Multi-component reaction
  • N-acyl amino acids
  • Palladium

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