A Neural Representation of Naturalistic Motion-Guided Behavior in the Zebrafish Brain

Tugce Yildizoglu, Clemens Riegler, James E. Fitzgerald, Ruben Portugues

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

All animals must transform ambiguous sensory data into successful behavior. This requires sensory representations that accurately reflect the statistics of natural stimuli and behavior. Multiple studies show that visual motion processing is tuned for accuracy under naturalistic conditions, but the sensorimotor circuits extracting these cues and implementing motion-guided behavior remain unclear. Here we show that the larval zebrafish retina extracts a diversity of naturalistic motion cues, and the retinorecipient pretectum organizes these cues around the elements of behavior. We find that higher-order motion stimuli, gliders, induce optomotor behavior matching expectations from natural scene analyses. We then image activity of retinal ganglion cell terminals and pretectal neurons. The retina exhibits direction-selective responses across glider stimuli, and anatomically clustered pretectal neurons respond with magnitudes matching behavior. Peripheral computations thus reflect natural input statistics, whereas central brain activity precisely codes information needed for behavior. This general principle could organize sensorimotor transformations across animal species.

Original languageEnglish
Pages (from-to)2321-2333.e6
JournalCurrent Biology
Volume30
Issue number12
DOIs
StatePublished - 22 Jun 2020

Keywords

  • arborization fields
  • glider stimuli
  • motion vision
  • naturalistic images
  • optomotor response
  • pretectum
  • wholebrain imaging
  • zebrafish

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