A Neural Circuit Arbitrates between Persistence and Withdrawal in Hungry Drosophila

Sercan Sayin; Jean Francois De Backer; K. P. Siju; Marina E. Wosniack; Laurence P. Lewis; Lisa Marie Frisch; Benedikt Gansen; Philipp Schlegel; Amelia Edmondson-Stait; Nadiya Sharifi; Corey B. Fisher; Steven A. Calle-Schuler; J. Scott Lauritzen; Davi D. Bock; Marta Costa; Gregory S.X.E. Jefferis; Julijana Gjorgjieva; Ilona C. Grunwald Kadow

doi:10.1016/j.neuron.2019.07.028

A Neural Circuit Arbitrates between Persistence and Withdrawal in Hungry Drosophila

Sercan Sayin, Jean Francois De Backer, K. P. Siju, Marina E. Wosniack, Laurence P. Lewis, Lisa Marie Frisch, Benedikt Gansen, Philipp Schlegel, Amelia Edmondson-Stait, Nadiya Sharifi, Corey B. Fisher, Steven A. Calle-Schuler, J. Scott Lauritzen, Davi D. Bock, Marta Costa, Gregory S.X.E. Jefferis, Julijana Gjorgjieva, Ilona C. Grunwald Kadow

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

What drives behavioral persistence versus quitting? Sayin et al. propose that circuit modules in the fly's learning center and dopamine drive gradually increasing food odor tracking, which can be efficiently suppressed by extrinsic, but directly innervating, feeding-related neuromodulatory neurons.

Original language	English
Pages (from-to)	544-558.e6
Journal	Neuron
Volume	104
Issue number	3
DOIs	https://doi.org/10.1016/j.neuron.2019.07.028
State	Published - 6 Nov 2019

Keywords

DopR2
Drosophila melanogaster
dopamine
foraging
goal-directed behavior
learning
mushroom body
octopamine
olfactory system
persistence

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10.1016/j.neuron.2019.07.028

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Sayin, S., De Backer, J. F., Siju, K. P., Wosniack, M. E., Lewis, L. P., Frisch, L. M., Gansen, B., Schlegel, P., Edmondson-Stait, A., Sharifi, N., Fisher, C. B., Calle-Schuler, S. A., Lauritzen, J. S., Bock, D. D., Costa, M., Jefferis, G. S. X. E., Gjorgjieva, J., & Grunwald Kadow, I. C. (2019). A Neural Circuit Arbitrates between Persistence and Withdrawal in Hungry Drosophila. Neuron, 104(3), 544-558.e6. https://doi.org/10.1016/j.neuron.2019.07.028

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title = "A Neural Circuit Arbitrates between Persistence and Withdrawal in Hungry Drosophila",

abstract = "What drives behavioral persistence versus quitting? Sayin et al. propose that circuit modules in the fly's learning center and dopamine drive gradually increasing food odor tracking, which can be efficiently suppressed by extrinsic, but directly innervating, feeding-related neuromodulatory neurons.",

keywords = "DopR2, Drosophila melanogaster, dopamine, foraging, goal-directed behavior, learning, mushroom body, octopamine, olfactory system, persistence",

author = "Sercan Sayin and {De Backer}, {Jean Francois} and Siju, {K. P.} and Wosniack, {Marina E.} and Lewis, {Laurence P.} and Frisch, {Lisa Marie} and Benedikt Gansen and Philipp Schlegel and Amelia Edmondson-Stait and Nadiya Sharifi and Fisher, {Corey B.} and Calle-Schuler, {Steven A.} and Lauritzen, {J. Scott} and Bock, {Davi D.} and Marta Costa and Jefferis, {Gregory S.X.E.} and Julijana Gjorgjieva and {Grunwald Kadow}, {Ilona C.}",

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year = "2019",

month = nov,

day = "6",

doi = "10.1016/j.neuron.2019.07.028",

language = "English",

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Sayin, S, De Backer, JF, Siju, KP, Wosniack, ME, Lewis, LP, Frisch, LM, Gansen, B, Schlegel, P, Edmondson-Stait, A, Sharifi, N, Fisher, CB, Calle-Schuler, SA, Lauritzen, JS, Bock, DD, Costa, M, Jefferis, GSXE, Gjorgjieva, J & Grunwald Kadow, IC 2019, 'A Neural Circuit Arbitrates between Persistence and Withdrawal in Hungry Drosophila', Neuron, vol. 104, no. 3, pp. 544-558.e6. https://doi.org/10.1016/j.neuron.2019.07.028

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T1 - A Neural Circuit Arbitrates between Persistence and Withdrawal in Hungry Drosophila

AU - Sayin, Sercan

AU - De Backer, Jean Francois

AU - Siju, K. P.

AU - Wosniack, Marina E.

AU - Lewis, Laurence P.

AU - Frisch, Lisa Marie

AU - Gansen, Benedikt

AU - Schlegel, Philipp

AU - Edmondson-Stait, Amelia

AU - Sharifi, Nadiya

AU - Fisher, Corey B.

AU - Calle-Schuler, Steven A.

AU - Lauritzen, J. Scott

AU - Bock, Davi D.

AU - Costa, Marta

AU - Jefferis, Gregory S.X.E.

AU - Gjorgjieva, Julijana

AU - Grunwald Kadow, Ilona C.

PY - 2019/11/6

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KW - DopR2

KW - Drosophila melanogaster

KW - dopamine

KW - foraging

KW - goal-directed behavior

KW - learning

KW - mushroom body

KW - octopamine

KW - olfactory system

KW - persistence

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AN - SCOPUS:85074239357

SN - 0896-6273

VL - 104

SP - 544-558.e6

JO - Neuron

JF - Neuron

IS - 3

ER -

A Neural Circuit Arbitrates between Persistence and Withdrawal in Hungry Drosophila

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