A naturally occurring opioid peptide from cow’s milk, beta-casomorphine-7, is a direct histamine releaser in man

M. Kurek, B. Przybilla, K. Hermann, J. Ring

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

β-Casomorphine-7, a naturally occurring product of cow’s milk with opiate-like activity, was studied for possible direct histamine liberation activities in humans. It was found to cause concentration-dependent in vitro histamine release from peripheral leukocytes of healthy adult volunteers. Intradermal injectionof β-casomorphine-7 induced a wheal and flare reaction in the skin similarto histamine or codeine. Oral pretreatment with the H1 antagonist terfenadine significantly inhibited the skin responses to β-Casomorphine-7. The intradermal injection of an opiate receptor antagonist, naloxone, inhibited in vitro histamine release and skin reactions only in a 100-fold excess over β-Casomorphine-7. These findings suggest that β-Casomorphine-7 can be regarded as a noncytotoxic, direct histamine releaser in humans. The clinical relevance of these findings deserves further studies.

Original languageEnglish
Pages (from-to)115-120
Number of pages6
JournalInternational Archives of Allergy and Immunology
Volume97
Issue number2
DOIs
StatePublished - 1992
Externally publishedYes

Keywords

  • Cow’s milk
  • Opioids histamine
  • β-Casomorphine-7

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