A Mild and Base-Free Protocol for the Ruthenium-Catalyzed Hydrogenation of Aliphatic and Aromatic Nitriles with Tridentate Phosphine Ligands

Rosa Adam, Charles Beromeo Bheeter, Ralf Jackstell, Matthias Beller

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

A novel protocol for the general hydrogenation of nitriles in the absence of basic additives is described. The system is based on the combination of [Ru(cod)(methylallyl)2] (cod=cyclooctadiene) and L2. A variety of aromatic and aliphatic nitriles is hydrogenated under mild conditions (50 °C and 15 bar H2) with this system. Kinetic studies revealed higher activity in the case of aromatic nitriles compared with aliphatic ones.

Original languageEnglish
Pages (from-to)1329-1334
Number of pages6
JournalChemCatChem
Volume8
Issue number7
DOIs
StatePublished - 6 Apr 2016
Externally publishedYes

Keywords

  • amines
  • hydrogenation
  • nitriles
  • phosphine ligands
  • ruthenium

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