A metal-free protocol for the preparation of amines using ammonia borane under mild conditions

Xinmin Li, Yue Hu, Asma M. Alenad, Bei Zhou, Zhuang Ma, Jie Gao, Rajenahally V. Jagadeesh, Matthias Beller

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

A mild and convenient reductive amination protocol for the synthesis of structurally diverse secondary and tertiary amines as well as N-methylated products under metal-free conditions is presented. This one-pot protocol works efficiently at room temperature using ammonia borane as the reductant and is applicable to a wide range of substrates, including chiral amines and amino acid derivatives. The synthetic utility and practicability of this methodology is demonstrated by gram-scale reactions and selected synthesis of current drug molecules.

Original languageEnglish
Pages (from-to)970-976
Number of pages7
JournalOrganic Chemistry Frontiers
Volume10
Issue number4
DOIs
StatePublished - 29 Dec 2022
Externally publishedYes

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