A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease

Ali Amin Al Olama; Zsofia Kote-Jarai; Fredrick R. Schumacher; Fredrik Wiklund; Sonja I. Berndt; Sara Benlloch; Graham G. Giles; Gianluca Severi; David E. Neal; Freddie C. Hamdy; Jenny L. Donovan; David J. Hunter; Brian E. Henderson; Michael J. Thun; Michael Gaziano; Edward L. Giovannucci; Afshan Siddiq; Ruth C. Travis; David G. Cox; Federico Canzian; Elio Riboli; Timothy J. Key; Gerald Andriole; Demetrius Albanes; Richard B. Hayes; Johanna Schleutker; Anssi Auvinen; Teuvo L.J. Tammela; Maren Weischer; Janet L. Stanford; Elaine A. Ostrander; Cezary Cybulski; Jan Lubinski; Stephen N. Thibodeau; Daniel J. Schaid; Karina D. Sorensen; Jyotsna Batra; Judith A. Clements; Suzanne Chambers; Joanne Aitken; Robert A. Gardiner; Christiane Maier; Walther Vogel; Thilo Dörk; Hermann Brenner; Tomonori Habuchi; Sue Ingles; Esther M. John; Joanne L. Dickinson; Lisa Cannon-Albright; Manuel R. Teixeira; Radka Kaneva; Hong Wei Zhang; Yong Jie Lu; Jong Y. Park; Kathleen A. Cooney; Kenneth R. Muir; Daniel A. Leongamornlert; Edward Saunders; Malgorzata Tymrakiewicz; Nadiya Mahmud; Michelle Guy; Koveela Govindasami; Lynne T. O'Brien; Rosemary A. Wilkinson; Amanda L. Hall; Emma J. Sawyer; Tokhir Dadaev; Jonathan Morrison; David P. Dearnaley; Alan Horwich; Robert A. Huddart; Vincent S. Khoo; Christopher C. Parker; Nicholas Van As; Christopher J. Woodhouse; Alan Thompson; Tim Dudderidge; Chris Ogden; Colin S. Cooper; Artitaya Lophatonanon; Melissa C. Southey; John L. Hopper; Dallas English; Jarmo Virtamo; Loic Le Marchand; Daniele Campa; Rudolf Kaaks; Sara Lindstrom; W. Ryan Diver; Susan Gapstur; Meredith Yeager; Angela Cox; Mariana C. Stern; Roman Corral; Markus Aly; William Isaacs; Jan Adolfsson; Jianfeng Xu; S. Lilly Zheng; Tiina Wahlfors; Kimmo Taari; Paula Kujala; Peter Klarskov; Børge G. Nordestgaard; M. Andreas Røder; Ruth Frikke-Schmidt; Stig E. Bojesen; Liesel M. FitzGerald; Suzanne Kolb; Erika M. Kwon; Danielle M. Karyadi; Torben Falck Orntoft; Michael Borre; Antje Rinckleb; Manuel Luedeke; Kathleen Herkommer; Andreas Meyer; Jü rgen Serth; James R. Marthick; Briony Patterson; Dominika Wokolorczyk; Amanda Spurdle; Felicity Lose; Shannon K. McDonnell; Amit D. Joshi; Ahva Shahabi; Pedro Pinto; Joana Santos; Ana Ray; Thomas A. Sellers; Hui Yi Lin; Robert A. Stephenson; Craig Teerlink; Heiko Muller; Dietrich Rothenbacher; Norihiko Tsuchiya; Shintaro Narita; Guang Wen Cao; Chavdar Slavov; Vanio Mitev; Stephen Chanock; Henrik Gronberg; Christopher A. Haiman; Peter Kraft; Douglas F. Easton; Rosalind A. Eeles

doi:10.1093/hmg/dds425

A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease

Ali Amin Al Olama
, Zsofia Kote-Jarai
, Fredrick R. Schumacher
, Fredrik Wiklund
, Sonja I. Berndt
, Sara Benlloch
, Graham G. Giles
, Gianluca Severi
, David E. Neal
, Freddie C. Hamdy
, Jenny L. Donovan
, David J. Hunter
, Brian E. Henderson
, Michael J. Thun
, Michael Gaziano
, Edward L. Giovannucci
, Afshan Siddiq
, Ruth C. Travis
, David G. Cox
, Federico Canzian

Elio Riboli, Timothy J. Key, Gerald Andriole, Demetrius Albanes, Richard B. Hayes, Johanna Schleutker, Anssi Auvinen, Teuvo L.J. Tammela, Maren Weischer, Janet L. Stanford, Elaine A. Ostrander, Cezary Cybulski, Jan Lubinski, Stephen N. Thibodeau, Daniel J. Schaid, Karina D. Sorensen, Jyotsna Batra, Judith A. Clements, Suzanne Chambers, Joanne Aitken, Robert A. Gardiner, Christiane Maier, Walther Vogel, Thilo Dörk, Hermann Brenner, Tomonori Habuchi, Sue Ingles, Esther M. John, Joanne L. Dickinson, Lisa Cannon-Albright, Manuel R. Teixeira, Radka Kaneva, Hong Wei Zhang, Yong Jie Lu, Jong Y. Park, Kathleen A. Cooney, Kenneth R. Muir, Daniel A. Leongamornlert, Edward Saunders, Malgorzata Tymrakiewicz, Nadiya Mahmud, Michelle Guy, Koveela Govindasami, Lynne T. O'Brien, Rosemary A. Wilkinson, Amanda L. Hall, Emma J. Sawyer, Tokhir Dadaev, Jonathan Morrison, David P. Dearnaley, Alan Horwich, Robert A. Huddart, Vincent S. Khoo, Christopher C. Parker, Nicholas Van As, Christopher J. Woodhouse, Alan Thompson, Tim Dudderidge, Chris Ogden, Colin S. Cooper, Artitaya Lophatonanon, Melissa C. Southey, John L. Hopper, Dallas English, Jarmo Virtamo, Loic Le Marchand, Daniele Campa, Rudolf Kaaks, Sara Lindstrom, W. Ryan Diver, Susan Gapstur, Meredith Yeager, Angela Cox, Mariana C. Stern, Roman Corral, Markus Aly, William Isaacs, Jan Adolfsson, Jianfeng Xu, S. Lilly Zheng, Tiina Wahlfors, Kimmo Taari, Paula Kujala, Peter Klarskov, Børge G. Nordestgaard, M. Andreas Røder, Ruth Frikke-Schmidt, Stig E. Bojesen, Liesel M. FitzGerald, Suzanne Kolb, Erika M. Kwon, Danielle M. Karyadi, Torben Falck Orntoft, Michael Borre, Antje Rinckleb, Manuel Luedeke, Kathleen Herkommer, Andreas Meyer, Jü rgen Serth, James R. Marthick, Briony Patterson, Dominika Wokolorczyk, Amanda Spurdle, Felicity Lose, Shannon K. McDonnell, Amit D. Joshi, Ahva Shahabi, Pedro Pinto, Joana Santos, Ana Ray, Thomas A. Sellers, Hui Yi Lin, Robert A. Stephenson, Craig Teerlink, Heiko Muller, Dietrich Rothenbacher, Norihiko Tsuchiya, Shintaro Narita, Guang Wen Cao, Chavdar Slavov, Vanio Mitev, Stephen Chanock, Henrik Gronberg, Christopher A. Haiman, Peter Kraft, Douglas F. Easton, Rosalind A. Eeles

Department of Urology

Strangeways Research Laboratory
Institute of Cancer Research
University of Southern California
Karolinska Institutet
National Cancer Institute (NCI)
Cancer Council Victoria
University of Melbourne
University of Cambridge
Cancer Research UK Cambridge Institute
University of Oxford
University of Bristol
Program in Molecular and Genetic Epidemiology
American Cancer Society
Boston Veterans Affairs Healthcare System
Brigham and Women's Hospital
Harvard T.H. Chan School of Public Health
Imperial College London
University of Lyon
German Cancer Research Center
Washington University School of Medicine in St. Louis
NYU-Langone Medical Center
Tampere University
University of Turku and Turku University Hospital
Tampere University Hospital
Gentofte Hospital
Fred Hutchinson Cancer Research Center
University of Washington
National Human Genome Research Institute (NHGRI)
Pomeranian Medical University in Szczecin
Mayo Clinic
Aarhus University
Queensland University of Technology
Menzies Health Institute Queensland
Viertel Centre for Research in Cancer Control
University of Queensland
University Medical Center Ulm and Center of Excellence 'Metabolic Disorders'
Medizinische Hochschule Hannover
Graduate School of Medicine
Cancer Prevention Institute of California
Stanford Cancer Institute
University of Tasmania
University of Utah School of Medicine
Edward Hines VA Medical Center
Inst. Portugues Oncologia
Medical University of Sofia
Second Military Medical University
Barts and The London School of Medicine and Dentistry
Moffitt Cancer Center
University of Michigan Medical School
Warwick Medical School
The Royal Marsden NHS Foundation Trust
National Institute for Health and Welfare
University of Hawaii Cancer Center
University of Sheffield
Department of Clinical Sciences, Danderyd Hospital
Johns Hopkins School of Medicine
Wake Forest School of Medicine
Helsinki University Central Hospital
Copenhagen University Hospital
Rigshospitalet
Huntsman Cancer Institute
Queensland Institute of Medical Research
University Hospital “Queen Johanna,”

Research output: Contribution to journal › Article › peer-review

120 Scopus citations

Abstract

Genome-wide association studies (GWAS) have identified multiple common genetic variants associated with an increased risk of prostate cancer (PrCa), but these explain less than one-third of the heritability. To identify further susceptibility alleles, we conducted a meta-analysis of four GWAS including 5953 cases of aggressive PrCa and 11 463 controls (men without PrCa). We computed association tests for approximately 2.6 million SNPs and followed up the most significantSNPs by genotyping 49 121 samples in 29 studies through the international PRACTICAL and BPC3 consortia. We not only confirmed the association of a PrCa susceptibility locus, rs11672691 on chromosome 19, but also showed an association with aggressive PrCa [odds ratio = 1.12 (95% confidence interval 1.03-1.21), P = 1.4 × 10^-8]. This report describes a genetic variant which is associated with aggressive PrCa, which is a type of PrCa associated with a poorer prognosis.

Original language	English
Article number	dds425
Pages (from-to)	408-415
Number of pages	8
Journal	Human Molecular Genetics
Volume	22
Issue number	2
DOIs	https://doi.org/10.1093/hmg/dds425
State	Published - Jan 2013

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10.1093/hmg/dds425

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Al Olama, A. A., Kote-Jarai, Z., Schumacher, F. R., Wiklund, F., Berndt, S. I., Benlloch, S., Giles, G. G., Severi, G., Neal, D. E., Hamdy, F. C., Donovan, J. L., Hunter, D. J., Henderson, B. E., Thun, M. J., Gaziano, M., Giovannucci, E. L., Siddiq, A., Travis, R. C., Cox, D. G., ... Eeles, R. A. (2013). A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease. Human Molecular Genetics, 22(2), 408-415. Article dds425. https://doi.org/10.1093/hmg/dds425

@article{cdf47112dd554861b90d2d0f458ce514,

title = "A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease",

abstract = "Genome-wide association studies (GWAS) have identified multiple common genetic variants associated with an increased risk of prostate cancer (PrCa), but these explain less than one-third of the heritability. To identify further susceptibility alleles, we conducted a meta-analysis of four GWAS including 5953 cases of aggressive PrCa and 11 463 controls (men without PrCa). We computed association tests for approximately 2.6 million SNPs and followed up the most significantSNPs by genotyping 49 121 samples in 29 studies through the international PRACTICAL and BPC3 consortia. We not only confirmed the association of a PrCa susceptibility locus, rs11672691 on chromosome 19, but also showed an association with aggressive PrCa [odds ratio = 1.12 (95\% confidence interval 1.03-1.21), P = 1.4 × 10-8]. This report describes a genetic variant which is associated with aggressive PrCa, which is a type of PrCa associated with a poorer prognosis.",

author = "\{Al Olama\}, \{Ali Amin\} and Zsofia Kote-Jarai and Schumacher, \{Fredrick R.\} and Fredrik Wiklund and Berndt, \{Sonja I.\} and Sara Benlloch and Giles, \{Graham G.\} and Gianluca Severi and Neal, \{David E.\} and Hamdy, \{Freddie C.\} and Donovan, \{Jenny L.\} and Hunter, \{David J.\} and Henderson, \{Brian E.\} and Thun, \{Michael J.\} and Michael Gaziano and Giovannucci, \{Edward L.\} and Afshan Siddiq and Travis, \{Ruth C.\} and Cox, \{David G.\} and Federico Canzian and Elio Riboli and Key, \{Timothy J.\} and Gerald Andriole and Demetrius Albanes and Hayes, \{Richard B.\} and Johanna Schleutker and Anssi Auvinen and Tammela, \{Teuvo L.J.\} and Maren Weischer and Stanford, \{Janet L.\} and Ostrander, \{Elaine A.\} and Cezary Cybulski and Jan Lubinski and Thibodeau, \{Stephen N.\} and Schaid, \{Daniel J.\} and Sorensen, \{Karina D.\} and Jyotsna Batra and Clements, \{Judith A.\} and Suzanne Chambers and Joanne Aitken and Gardiner, \{Robert A.\} and Christiane Maier and Walther Vogel and Thilo D{\"o}rk and Hermann Brenner and Tomonori Habuchi and Sue Ingles and John, \{Esther M.\} and Dickinson, \{Joanne L.\} and Lisa Cannon-Albright and Teixeira, \{Manuel R.\} and Radka Kaneva and Zhang, \{Hong Wei\} and Lu, \{Yong Jie\} and Park, \{Jong Y.\} and Cooney, \{Kathleen A.\} and Muir, \{Kenneth R.\} and Leongamornlert, \{Daniel A.\} and Edward Saunders and Malgorzata Tymrakiewicz and Nadiya Mahmud and Michelle Guy and Koveela Govindasami and O'Brien, \{Lynne T.\} and Wilkinson, \{Rosemary A.\} and Hall, \{Amanda L.\} and Sawyer, \{Emma J.\} and Tokhir Dadaev and Jonathan Morrison and Dearnaley, \{David P.\} and Alan Horwich and Huddart, \{Robert A.\} and Khoo, \{Vincent S.\} and Parker, \{Christopher C.\} and \{Van As\}, Nicholas and Woodhouse, \{Christopher J.\} and Alan Thompson and Tim Dudderidge and Chris Ogden and Cooper, \{Colin S.\} and Artitaya Lophatonanon and Southey, \{Melissa C.\} and Hopper, \{John L.\} and Dallas English and Jarmo Virtamo and Marchand, \{Loic Le\} and Daniele Campa and Rudolf Kaaks and Sara Lindstrom and Diver, \{W. Ryan\} and Susan Gapstur and Meredith Yeager and Angela Cox and Stern, \{Mariana C.\} and Roman Corral and Markus Aly and William Isaacs and Jan Adolfsson and Jianfeng Xu and Zheng, \{S. Lilly\} and Tiina Wahlfors and Kimmo Taari and Paula Kujala and Peter Klarskov and Nordestgaard, \{B{\o}rge G.\} and R{\o}der, \{M. Andreas\} and Ruth Frikke-Schmidt and Bojesen, \{Stig E.\} and FitzGerald, \{Liesel M.\} and Suzanne Kolb and Kwon, \{Erika M.\} and Karyadi, \{Danielle M.\} and Orntoft, \{Torben Falck\} and Michael Borre and Antje Rinckleb and Manuel Luedeke and Kathleen Herkommer and Andreas Meyer and Serth, \{J{\"u} rgen\} and Marthick, \{James R.\} and Briony Patterson and Dominika Wokolorczyk and Amanda Spurdle and Felicity Lose and McDonnell, \{Shannon K.\} and Joshi, \{Amit D.\} and Ahva Shahabi and Pedro Pinto and Joana Santos and Ana Ray and Sellers, \{Thomas A.\} and Lin, \{Hui Yi\} and Stephenson, \{Robert A.\} and Craig Teerlink and Heiko Muller and Dietrich Rothenbacher and Norihiko Tsuchiya and Shintaro Narita and Cao, \{Guang Wen\} and Chavdar Slavov and Vanio Mitev and Stephen Chanock and Henrik Gronberg and Haiman, \{Christopher A.\} and Peter Kraft and Easton, \{Douglas F.\} and Eeles, \{Rosalind A.\}",

note = "Funding Information: This work was supported by Cancer Research UK grants (grant numbers: C5047/A7357, C1287/A10118, C5047/ A3354, C5047/A10692, C16913/A6135) and The National Institute of Health (NIH) Cancer Post-Cancer GWAS initiative grant (grant number: 1 U19 CA 148537-01 (the GAME-ON initiative)). Further support is detailed in Supplementary Material, Notes.",

year = "2013",

month = jan,

doi = "10.1093/hmg/dds425",

language = "English",

volume = "22",

pages = "408--415",

journal = "Human Molecular Genetics",

issn = "0964-6906",

publisher = "Oxford University Press",

number = "2",

}

Al Olama, AA, Kote-Jarai, Z, Schumacher, FR, Wiklund, F, Berndt, SI, Benlloch, S, Giles, GG, Severi, G, Neal, DE, Hamdy, FC, Donovan, JL, Hunter, DJ, Henderson, BE, Thun, MJ, Gaziano, M, Giovannucci, EL, Siddiq, A, Travis, RC, Cox, DG, Canzian, F, Riboli, E, Key, TJ, Andriole, G, Albanes, D, Hayes, RB, Schleutker, J, Auvinen, A, Tammela, TLJ, Weischer, M, Stanford, JL, Ostrander, EA, Cybulski, C, Lubinski, J, Thibodeau, SN, Schaid, DJ, Sorensen, KD, Batra, J, Clements, JA, Chambers, S, Aitken, J, Gardiner, RA, Maier, C, Vogel, W, Dörk, T, Brenner, H, Habuchi, T, Ingles, S, John, EM, Dickinson, JL, Cannon-Albright, L, Teixeira, MR, Kaneva, R, Zhang, HW, Lu, YJ, Park, JY, Cooney, KA, Muir, KR, Leongamornlert, DA, Saunders, E, Tymrakiewicz, M, Mahmud, N, Guy, M, Govindasami, K, O'Brien, LT, Wilkinson, RA, Hall, AL, Sawyer, EJ, Dadaev, T, Morrison, J, Dearnaley, DP, Horwich, A, Huddart, RA, Khoo, VS, Parker, CC, Van As, N, Woodhouse, CJ, Thompson, A, Dudderidge, T, Ogden, C, Cooper, CS, Lophatonanon, A, Southey, MC, Hopper, JL, English, D, Virtamo, J, Marchand, LL, Campa, D, Kaaks, R, Lindstrom, S, Diver, WR, Gapstur, S, Yeager, M, Cox, A, Stern, MC, Corral, R, Aly, M, Isaacs, W, Adolfsson, J, Xu, J, Zheng, SL, Wahlfors, T, Taari, K, Kujala, P, Klarskov, P, Nordestgaard, BG, Røder, MA, Frikke-Schmidt, R, Bojesen, SE, FitzGerald, LM, Kolb, S, Kwon, EM, Karyadi, DM, Orntoft, TF, Borre, M, Rinckleb, A, Luedeke, M, Herkommer, K, Meyer, A, Serth, JR, Marthick, JR, Patterson, B, Wokolorczyk, D, Spurdle, A, Lose, F, McDonnell, SK, Joshi, AD, Shahabi, A, Pinto, P, Santos, J, Ray, A, Sellers, TA, Lin, HY, Stephenson, RA, Teerlink, C, Muller, H, Rothenbacher, D, Tsuchiya, N, Narita, S, Cao, GW, Slavov, C, Mitev, V, Chanock, S, Gronberg, H, Haiman, CA, Kraft, P, Easton, DF & Eeles, RA 2013, 'A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease', Human Molecular Genetics, vol. 22, no. 2, dds425, pp. 408-415. https://doi.org/10.1093/hmg/dds425

TY - JOUR

T1 - A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease

AU - Al Olama, Ali Amin

AU - Kote-Jarai, Zsofia

AU - Schumacher, Fredrick R.

AU - Wiklund, Fredrik

AU - Berndt, Sonja I.

AU - Benlloch, Sara

AU - Giles, Graham G.

AU - Severi, Gianluca

AU - Neal, David E.

AU - Hamdy, Freddie C.

AU - Donovan, Jenny L.

AU - Hunter, David J.

AU - Henderson, Brian E.

AU - Thun, Michael J.

AU - Gaziano, Michael

AU - Giovannucci, Edward L.

AU - Siddiq, Afshan

AU - Travis, Ruth C.

AU - Cox, David G.

AU - Canzian, Federico

AU - Riboli, Elio

AU - Key, Timothy J.

AU - Andriole, Gerald

AU - Albanes, Demetrius

AU - Hayes, Richard B.

AU - Schleutker, Johanna

AU - Auvinen, Anssi

AU - Tammela, Teuvo L.J.

AU - Weischer, Maren

AU - Stanford, Janet L.

AU - Ostrander, Elaine A.

AU - Cybulski, Cezary

AU - Lubinski, Jan

AU - Thibodeau, Stephen N.

AU - Schaid, Daniel J.

AU - Sorensen, Karina D.

AU - Batra, Jyotsna

AU - Clements, Judith A.

AU - Chambers, Suzanne

AU - Aitken, Joanne

AU - Gardiner, Robert A.

AU - Maier, Christiane

AU - Vogel, Walther

AU - Dörk, Thilo

AU - Brenner, Hermann

AU - Habuchi, Tomonori

AU - Ingles, Sue

AU - John, Esther M.

AU - Dickinson, Joanne L.

AU - Cannon-Albright, Lisa

AU - Teixeira, Manuel R.

AU - Kaneva, Radka

AU - Zhang, Hong Wei

AU - Lu, Yong Jie

AU - Park, Jong Y.

AU - Cooney, Kathleen A.

AU - Muir, Kenneth R.

AU - Leongamornlert, Daniel A.

AU - Saunders, Edward

AU - Tymrakiewicz, Malgorzata

AU - Mahmud, Nadiya

AU - Guy, Michelle

AU - Govindasami, Koveela

AU - O'Brien, Lynne T.

AU - Wilkinson, Rosemary A.

AU - Hall, Amanda L.

AU - Sawyer, Emma J.

AU - Dadaev, Tokhir

AU - Morrison, Jonathan

AU - Dearnaley, David P.

AU - Horwich, Alan

AU - Huddart, Robert A.

AU - Khoo, Vincent S.

AU - Parker, Christopher C.

AU - Van As, Nicholas

AU - Woodhouse, Christopher J.

AU - Thompson, Alan

AU - Dudderidge, Tim

AU - Ogden, Chris

AU - Cooper, Colin S.

AU - Lophatonanon, Artitaya

AU - Southey, Melissa C.

AU - Hopper, John L.

AU - English, Dallas

AU - Virtamo, Jarmo

AU - Marchand, Loic Le

AU - Campa, Daniele

AU - Kaaks, Rudolf

AU - Lindstrom, Sara

AU - Diver, W. Ryan

AU - Gapstur, Susan

AU - Yeager, Meredith

AU - Cox, Angela

AU - Stern, Mariana C.

AU - Corral, Roman

AU - Aly, Markus

AU - Isaacs, William

AU - Adolfsson, Jan

AU - Xu, Jianfeng

AU - Zheng, S. Lilly

AU - Wahlfors, Tiina

AU - Taari, Kimmo

AU - Kujala, Paula

AU - Klarskov, Peter

AU - Nordestgaard, Børge G.

AU - Røder, M. Andreas

AU - Frikke-Schmidt, Ruth

AU - Bojesen, Stig E.

AU - FitzGerald, Liesel M.

AU - Kolb, Suzanne

AU - Kwon, Erika M.

AU - Karyadi, Danielle M.

AU - Orntoft, Torben Falck

AU - Borre, Michael

AU - Rinckleb, Antje

AU - Luedeke, Manuel

AU - Herkommer, Kathleen

AU - Meyer, Andreas

AU - Serth, Jü rgen

AU - Marthick, James R.

AU - Patterson, Briony

AU - Wokolorczyk, Dominika

AU - Spurdle, Amanda

AU - Lose, Felicity

AU - McDonnell, Shannon K.

AU - Joshi, Amit D.

AU - Shahabi, Ahva

AU - Pinto, Pedro

AU - Santos, Joana

AU - Ray, Ana

AU - Sellers, Thomas A.

AU - Lin, Hui Yi

AU - Stephenson, Robert A.

AU - Teerlink, Craig

AU - Muller, Heiko

AU - Rothenbacher, Dietrich

AU - Tsuchiya, Norihiko

AU - Narita, Shintaro

AU - Cao, Guang Wen

AU - Slavov, Chavdar

AU - Mitev, Vanio

AU - Chanock, Stephen

AU - Gronberg, Henrik

AU - Haiman, Christopher A.

AU - Kraft, Peter

AU - Easton, Douglas F.

AU - Eeles, Rosalind A.

N1 - Funding Information: This work was supported by Cancer Research UK grants (grant numbers: C5047/A7357, C1287/A10118, C5047/ A3354, C5047/A10692, C16913/A6135) and The National Institute of Health (NIH) Cancer Post-Cancer GWAS initiative grant (grant number: 1 U19 CA 148537-01 (the GAME-ON initiative)). Further support is detailed in Supplementary Material, Notes.

PY - 2013/1

Y1 - 2013/1

N2 - Genome-wide association studies (GWAS) have identified multiple common genetic variants associated with an increased risk of prostate cancer (PrCa), but these explain less than one-third of the heritability. To identify further susceptibility alleles, we conducted a meta-analysis of four GWAS including 5953 cases of aggressive PrCa and 11 463 controls (men without PrCa). We computed association tests for approximately 2.6 million SNPs and followed up the most significantSNPs by genotyping 49 121 samples in 29 studies through the international PRACTICAL and BPC3 consortia. We not only confirmed the association of a PrCa susceptibility locus, rs11672691 on chromosome 19, but also showed an association with aggressive PrCa [odds ratio = 1.12 (95% confidence interval 1.03-1.21), P = 1.4 × 10-8]. This report describes a genetic variant which is associated with aggressive PrCa, which is a type of PrCa associated with a poorer prognosis.

AB - Genome-wide association studies (GWAS) have identified multiple common genetic variants associated with an increased risk of prostate cancer (PrCa), but these explain less than one-third of the heritability. To identify further susceptibility alleles, we conducted a meta-analysis of four GWAS including 5953 cases of aggressive PrCa and 11 463 controls (men without PrCa). We computed association tests for approximately 2.6 million SNPs and followed up the most significantSNPs by genotyping 49 121 samples in 29 studies through the international PRACTICAL and BPC3 consortia. We not only confirmed the association of a PrCa susceptibility locus, rs11672691 on chromosome 19, but also showed an association with aggressive PrCa [odds ratio = 1.12 (95% confidence interval 1.03-1.21), P = 1.4 × 10-8]. This report describes a genetic variant which is associated with aggressive PrCa, which is a type of PrCa associated with a poorer prognosis.

UR - https://www.scopus.com/pages/publications/84871603324

U2 - 10.1093/hmg/dds425

DO - 10.1093/hmg/dds425

M3 - Article

C2 - 23065704

AN - SCOPUS:84871603324

SN - 0964-6906

VL - 22

SP - 408

EP - 415

JO - Human Molecular Genetics

JF - Human Molecular Genetics

IS - 2

M1 - dds425

ER -

A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease

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