A ligand structure-enantioselectivity relationship for the osmium-catalyzed asymmetric dihydroxylation of olefins

Yasukazu Ogino, Hou Chen, Eric Manoury, Tomoyuki Shibata, Matthias Beller, Doris Lübben, K. Barry Sharpless

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

The highest enantioselectivities to date for various olefins are obtained in the osmium-catalyzed asymmetric dihydroxylation using new 9-O-aromatic dihydroquinidine and dihydroquinine ligands. A ligand structure-enantioselectivity relationship (LSER) is developed, and representative results for quinine-based ligands are reported for the first time.

Original languageEnglish
Pages (from-to)5761-5764
Number of pages4
JournalTetrahedron Letters
Volume32
Issue number41
DOIs
StatePublished - 7 Oct 1991
Externally publishedYes

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