Abstract
Independent component analysis (ICA) as well as blind source separation (BSS) often faces the problem of assigning the independent or uncorrelated components estimated with ICA or BSS techniques to underlying source signals, artifacts or noise contributions. In this work an automatic assignment tool is presented which uses a priori knowledge about the form of some of the signals to be extracted. The algorithm is applied to the problem of removing water artifacts from 2D NOESY NMR spectra. The algorithm uses local PCA to approximate the water artifact and defines a suitable cost function which is optimized using simulated annealing. The blind source separation of the water artifact from the remaining protein spectrum is done with the recently developed algorithm dAMUSE.
Original language | English |
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Pages (from-to) | 1075-1082 |
Number of pages | 8 |
Journal | Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) |
Volume | 3512 |
DOIs | |
State | Published - 2005 |
Externally published | Yes |
Event | 8th International Workshop on Artificial Neural Networks, IWANN 2005: Computational Intelligence and Bioinspired Systems - Vilanova i la Geltru, Spain Duration: 8 Jun 2005 → 10 Jun 2005 |