A Heat-Activated Drug-Delivery Platform Based on Phosphatidyl-(oligo)-glycerol Nanocarrier for Effective Cancer Treatment

Martin Hossann, Johannes Hirschberger, Rebecca Schmidt, Christine Baumgartner, Katja Zimmermann, Silke Baer, Christina Ratzlaff, Michael Peller, Karin Troedson, Simone Limmer, Andreas Brühschwein, Rene Dörfelt, Nina Kreutzmann, Gerhard Wess, Thomas Knösel, Olaf Schagon, Johannes Fischer, Holger Grüll, Linus Willerding, Michael SchmidtAndrea Meyer-Lindenberg, Rolf D. Issels, Markus Schwaiger, Alexander M. Eggermont, Timo L. ten Hagen, Lars H. Lindner

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

The potential of cancer drugs is not fully exploited due to low tumor uptake and occurrence of systemic side effects, limiting maximum tolerated dose. Actively targeted nanocarriers improve efficacy while minimizing off-target toxicity. Herein, it is the first time a drug-delivery platform for heat-triggered intravascular drug release is described, based on synthetic phosphatidyl-(oligo)-glycerols from organic synthesis to preclinical investigation in feline patients. For the nanocarrier formulated doxorubicin (DOX), superior tumor drug delivery and antitumor activity compared with free DOX, conventional liposomal DOX (Caelyx), and temperature-sensitive lysolipid-containing DOX-liposomes in rat sarcoma are demonstrated. In a comparative oncological study with neoadjuvant treatment of feline sarcoma, a metabolic response determined with 18 F-FDG-positron emission tomography/magnetic resonance imaging (PET/MRI) and histopathological response after tumor resection are significantly better compared with free DOX, potentially by overcoming drug resistance based on improved intratumoral drug distribution. This novel drug-delivery platform has great potential for the treatment of locally advanced tumors in humans.

Original languageEnglish
Article number2000089
JournalAdvanced NanoBiomed Research
Volume1
Issue number6
DOIs
StatePublished - Jun 2021
Externally publishedYes

Keywords

  • drug delivery
  • hyperthermia
  • nanomedicines
  • neoadjuvants
  • phosphatidyloligoglycerol
  • soft tissue sarcoma
  • thermosensitive liposomes

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