A glycopeptide dendrimer inhibitor of the galactose-specific lectin LecA and of pseudomonas aeruginosa biofilms

Rameshwar U. Kadam; Myriam Bergmann; Matthew Hurley; Divita Garg; Martina Cacciarini; Magdalena A. Swiderska; Cristina Nativi; Michael Sattler; Alan R. Smyth; Paul Williams; Miguel Cámara; Achim Stocker; Tamis Darbre; Jean Louis Reymond

doi:10.1002/anie.201104342

A glycopeptide dendrimer inhibitor of the galactose-specific lectin LecA and of pseudomonas aeruginosa biofilms

Rameshwar U. Kadam
, Myriam Bergmann
, Matthew Hurley
, Divita Garg
, Martina Cacciarini
, Magdalena A. Swiderska
, Cristina Nativi
, Michael Sattler
, Alan R. Smyth
, Paul Williams
, Miguel Cámara
, Achim Stocker
, Tamis Darbre
, Jean Louis Reymond

Chair of Biomolecular NMR-Spectroscopy

University of Bern
University of Nottingham
Technical University of Munich
University of Florence

Research output: Contribution to journal › Article › peer-review

168 Scopus citations

Abstract

Inhibiting factors: Biofilm inhibition is achieved with a phenylgalactosyl peptide dendrimer (see picture) that binds to the galactose-specific lectin LecA of P. aeruginosa. The multivalency of the ligands is critical for biofilm inhibition, although the nature of the linker between the peptide dendrimer and the galactose can provide additional contacts to the lectin and also has an effect on the interaction.

Original language	English
Pages (from-to)	10631-10635
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	45
DOIs	https://doi.org/10.1002/anie.201104342
State	Published - 4 Nov 2011

Keywords

biofilms
dendrimers
glycopeptides
lectins
multivalency

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10.1002/anie.201104342

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Kadam, R. U., Bergmann, M., Hurley, M., Garg, D., Cacciarini, M., Swiderska, M. A., Nativi, C., Sattler, M., Smyth, A. R., Williams, P., Cámara, M., Stocker, A., Darbre, T., & Reymond, J. L. (2011). A glycopeptide dendrimer inhibitor of the galactose-specific lectin LecA and of pseudomonas aeruginosa biofilms. Angewandte Chemie - International Edition, 50(45), 10631-10635. https://doi.org/10.1002/anie.201104342

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title = "A glycopeptide dendrimer inhibitor of the galactose-specific lectin LecA and of pseudomonas aeruginosa biofilms",

abstract = "Inhibiting factors: Biofilm inhibition is achieved with a phenylgalactosyl peptide dendrimer (see picture) that binds to the galactose-specific lectin LecA of P. aeruginosa. The multivalency of the ligands is critical for biofilm inhibition, although the nature of the linker between the peptide dendrimer and the galactose can provide additional contacts to the lectin and also has an effect on the interaction.",

keywords = "biofilms, dendrimers, glycopeptides, lectins, multivalency",

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Kadam, RU, Bergmann, M, Hurley, M, Garg, D, Cacciarini, M, Swiderska, MA, Nativi, C, Sattler, M, Smyth, AR, Williams, P, Cámara, M, Stocker, A, Darbre, T & Reymond, JL 2011, 'A glycopeptide dendrimer inhibitor of the galactose-specific lectin LecA and of pseudomonas aeruginosa biofilms', Angewandte Chemie - International Edition, vol. 50, no. 45, pp. 10631-10635. https://doi.org/10.1002/anie.201104342

TY - JOUR

T1 - A glycopeptide dendrimer inhibitor of the galactose-specific lectin LecA and of pseudomonas aeruginosa biofilms

AU - Kadam, Rameshwar U.

AU - Bergmann, Myriam

AU - Hurley, Matthew

AU - Garg, Divita

AU - Cacciarini, Martina

AU - Swiderska, Magdalena A.

AU - Nativi, Cristina

AU - Sattler, Michael

AU - Smyth, Alan R.

AU - Williams, Paul

AU - Cámara, Miguel

AU - Stocker, Achim

AU - Darbre, Tamis

AU - Reymond, Jean Louis

PY - 2011/11/4

Y1 - 2011/11/4

N2 - Inhibiting factors: Biofilm inhibition is achieved with a phenylgalactosyl peptide dendrimer (see picture) that binds to the galactose-specific lectin LecA of P. aeruginosa. The multivalency of the ligands is critical for biofilm inhibition, although the nature of the linker between the peptide dendrimer and the galactose can provide additional contacts to the lectin and also has an effect on the interaction.

AB - Inhibiting factors: Biofilm inhibition is achieved with a phenylgalactosyl peptide dendrimer (see picture) that binds to the galactose-specific lectin LecA of P. aeruginosa. The multivalency of the ligands is critical for biofilm inhibition, although the nature of the linker between the peptide dendrimer and the galactose can provide additional contacts to the lectin and also has an effect on the interaction.

KW - biofilms

KW - dendrimers

KW - glycopeptides

KW - lectins

KW - multivalency

UR - https://www.scopus.com/pages/publications/80155138272

U2 - 10.1002/anie.201104342

DO - 10.1002/anie.201104342

M3 - Article

C2 - 21919164

AN - SCOPUS:80155138272

SN - 1433-7851

VL - 50

SP - 10631

EP - 10635

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 45

ER -

A glycopeptide dendrimer inhibitor of the galactose-specific lectin LecA and of pseudomonas aeruginosa biofilms

Abstract

Keywords

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