A glycopeptide dendrimer inhibitor of the galactose-specific lectin LecA and of pseudomonas aeruginosa biofilms

Rameshwar U. Kadam; Myriam Bergmann; Matthew Hurley; Divita Garg; Martina Cacciarini; Magdalena A. Swiderska; Cristina Nativi; Michael Sattler; Alan R. Smyth; Paul Williams; Miguel Cámara; Achim Stocker; Tamis Darbre; Jean Louis Reymond

doi:10.1002/anie.201104342

A glycopeptide dendrimer inhibitor of the galactose-specific lectin LecA and of pseudomonas aeruginosa biofilms

Rameshwar U. Kadam, Myriam Bergmann, Matthew Hurley, Divita Garg, Martina Cacciarini, Magdalena A. Swiderska, Cristina Nativi, Michael Sattler, Alan R. Smyth, Paul Williams, Miguel Cámara, Achim Stocker, Tamis Darbre, Jean Louis Reymond

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Abstract

Inhibiting factors: Biofilm inhibition is achieved with a phenylgalactosyl peptide dendrimer (see picture) that binds to the galactose-specific lectin LecA of P. aeruginosa. The multivalency of the ligands is critical for biofilm inhibition, although the nature of the linker between the peptide dendrimer and the galactose can provide additional contacts to the lectin and also has an effect on the interaction.

Original language	English
Pages (from-to)	10631-10635
Number of pages	5
Journal	Angewandte Chemie International Edition in English
Volume	50
Issue number	45
DOIs	https://doi.org/10.1002/anie.201104342
State	Published - 4 Nov 2011

Keywords

biofilms
dendrimers
glycopeptides
lectins
multivalency

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Kadam, R. U., Bergmann, M., Hurley, M., Garg, D., Cacciarini, M., Swiderska, M. A., Nativi, C., Sattler, M., Smyth, A. R., Williams, P., Cámara, M., Stocker, A., Darbre, T., & Reymond, J. L. (2011). A glycopeptide dendrimer inhibitor of the galactose-specific lectin LecA and of pseudomonas aeruginosa biofilms. Angewandte Chemie International Edition in English, 50(45), 10631-10635. https://doi.org/10.1002/anie.201104342

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title = "A glycopeptide dendrimer inhibitor of the galactose-specific lectin LecA and of pseudomonas aeruginosa biofilms",

abstract = "Inhibiting factors: Biofilm inhibition is achieved with a phenylgalactosyl peptide dendrimer (see picture) that binds to the galactose-specific lectin LecA of P. aeruginosa. The multivalency of the ligands is critical for biofilm inhibition, although the nature of the linker between the peptide dendrimer and the galactose can provide additional contacts to the lectin and also has an effect on the interaction.",

keywords = "biofilms, dendrimers, glycopeptides, lectins, multivalency",

author = "Kadam, {Rameshwar U.} and Myriam Bergmann and Matthew Hurley and Divita Garg and Martina Cacciarini and Swiderska, {Magdalena A.} and Cristina Nativi and Michael Sattler and Smyth, {Alan R.} and Paul Williams and Miguel C{\'a}mara and Achim Stocker and Tamis Darbre and Reymond, {Jean Louis}",

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Kadam, RU, Bergmann, M, Hurley, M, Garg, D, Cacciarini, M, Swiderska, MA, Nativi, C, Sattler, M, Smyth, AR, Williams, P, Cámara, M, Stocker, A, Darbre, T & Reymond, JL 2011, 'A glycopeptide dendrimer inhibitor of the galactose-specific lectin LecA and of pseudomonas aeruginosa biofilms', Angewandte Chemie International Edition in English, vol. 50, no. 45, pp. 10631-10635. https://doi.org/10.1002/anie.201104342

TY - JOUR

T1 - A glycopeptide dendrimer inhibitor of the galactose-specific lectin LecA and of pseudomonas aeruginosa biofilms

AU - Kadam, Rameshwar U.

AU - Bergmann, Myriam

AU - Hurley, Matthew

AU - Garg, Divita

AU - Cacciarini, Martina

AU - Swiderska, Magdalena A.

AU - Nativi, Cristina

AU - Sattler, Michael

AU - Smyth, Alan R.

AU - Williams, Paul

AU - Cámara, Miguel

AU - Stocker, Achim

AU - Darbre, Tamis

AU - Reymond, Jean Louis

PY - 2011/11/4

Y1 - 2011/11/4

N2 - Inhibiting factors: Biofilm inhibition is achieved with a phenylgalactosyl peptide dendrimer (see picture) that binds to the galactose-specific lectin LecA of P. aeruginosa. The multivalency of the ligands is critical for biofilm inhibition, although the nature of the linker between the peptide dendrimer and the galactose can provide additional contacts to the lectin and also has an effect on the interaction.

AB - Inhibiting factors: Biofilm inhibition is achieved with a phenylgalactosyl peptide dendrimer (see picture) that binds to the galactose-specific lectin LecA of P. aeruginosa. The multivalency of the ligands is critical for biofilm inhibition, although the nature of the linker between the peptide dendrimer and the galactose can provide additional contacts to the lectin and also has an effect on the interaction.

KW - biofilms

KW - dendrimers

KW - glycopeptides

KW - lectins

KW - multivalency

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U2 - 10.1002/anie.201104342

DO - 10.1002/anie.201104342

M3 - Article

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AN - SCOPUS:80155138272

SN - 1433-7851

VL - 50

SP - 10631

EP - 10635

JO - Angewandte Chemie International Edition in English

JF - Angewandte Chemie International Edition in English

IS - 45

ER -

A glycopeptide dendrimer inhibitor of the galactose-specific lectin LecA and of pseudomonas aeruginosa biofilms

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