A general synthesis of diarylketones by means of a three-component cross-coupling of aryl and heteroaryl bromides, carbon monoxide, and boronic acids

Helfried Neumann, Anne Brennführer, Matthias Beller

Research output: Contribution to journalArticlepeer-review

134 Scopus citations

Abstract

Pd(OAc)2/di-1-adamantyl-n-butylphosphine (cataCXium A) is highly active in the three-component Suzuki carbonylation and represents the most general catalyst system reported up to now. A broad range of aryl/heteroaryl bromides and aryl boronic acids can be coupled to the corresponding diarylketones at low catalyst loadings.

Original languageEnglish
Pages (from-to)3645-3652
Number of pages8
JournalChemistry - A European Journal
Volume14
Issue number12
DOIs
StatePublished - 18 Apr 2008
Externally publishedYes

Keywords

  • Carbon monoxide
  • Diarylketones
  • Homogeneous catalysis
  • Palladium
  • Three-component reactions

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