A general synthesis of aromatic amides via palladium-catalyzed direct aminocarbonylation of aryl chlorides

Peng Wang, Ji Yang, Kangkang Sun, Helfried Neumann, Matthias Beller

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The direct palladium-catalyzed selective carbonylative coupling of less reactive aryl chlorides (including electron-rich, -neutral and -deficient ones) with primary and secondary aliphatic and aromatic amines is described for the first time. Key for the success of this transformation is the use of a palladium/Xantphos catalyst system in the presence of cesium chloride (CsCl) as additive. In general, this catalytic system allows for efficient conversion of diverse aryl chlorides with an array of amines and with good functional group compatibility (60 examples, conversion up to 99%, isolated yield up to 95%).

Original languageEnglish
Pages (from-to)2491-2497
Number of pages7
JournalOrganic Chemistry Frontiers
Volume9
Issue number9
DOIs
StatePublished - 22 Mar 2022
Externally publishedYes

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