A general rhodium-catalyzed cyanation of aryl and alkenyl boronic acids

Pazhamalai Anbarasan, Helfried Neumann, Matthias Beller

Research output: Contribution to journalArticlepeer-review

198 Scopus citations

Abstract

Give me a cyanide: N-cyano-N-phenyl-p-methylbenzenesulfonamide as a cyanation reagent allows the synthesis of aryl(alkenyl) nitriles in good yield under mild conditions (see scheme; cod=cycloocta-1,5-diene). Combination of the procedure with the direct borylation of arenes and hydroboration of alkynes leads to the straightforward synthesis of various nitriles.

Original languageEnglish
Pages (from-to)519-522
Number of pages4
JournalAngewandte Chemie International Edition in English
Volume50
Issue number2
DOIs
StatePublished - 10 Jan 2011
Externally publishedYes

Keywords

  • benzonitriles
  • boronic acids
  • cyanation
  • homogeneous catalysis
  • rhodium

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