A General Regioselective Synthesis of Alcohols by Cobalt-Catalyzed Hydrogenation of Epoxides

Weiping Liu, Thomas Leischner, Wu Li, Kathrin Junge, Matthias Beller

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

A straightforward methodology for the synthesis of anti-Markovnikov-type alcohols is presented. By using a specific cobalt triphos complex in the presence of Zn(OTf)2 as an additive, the hydrogenation of epoxides proceeds with high yields and selectivities. The described protocol shows a broad substrate scope, including multi-substituted internal and terminal epoxides, as well as a good functional-group tolerance. Various natural-product derivatives, including steroids, terpenoids, and sesquiterpenoids, gave access to the corresponding alcohols in moderate-to-excellent yields.

Original languageEnglish
Pages (from-to)11321-11324
Number of pages4
JournalAngewandte Chemie International Edition in English
Volume59
Issue number28
DOIs
StatePublished - 6 Jul 2020
Externally publishedYes

Keywords

  • anti-Markovnikov
  • cobalt
  • epoxides
  • homogeneous catalysis
  • hydrogenation

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