A general and selective iron-catalyzed aminocarbonylation of alkynes: Synthesis of acryl- and cinnamides

Katrin Marie Driller, Saisuree Prateeptongkum, Ralf Jackstell, Matthias Beller

Research output: Contribution to journalArticlepeer-review

99 Scopus citations

Abstract

Entering the iron age: The first general method for iron-catalyzed monocarbonylation of alkynes has been developed. A range of structurally diverse cinnamides and acrylamides have been obtained smoothly starting from commercially available amines and alkynes in the presence of [Fe 3(CO)12] and ligand L (see scheme). The method is highly chemo- and regioselective and requires no expensive catalyst.

Original languageEnglish
Pages (from-to)537-541
Number of pages5
JournalAngewandte Chemie International Edition in English
Volume50
Issue number2
DOIs
StatePublished - 10 Jan 2011
Externally publishedYes

Keywords

  • acrylamides
  • carbonylation
  • cinnamides
  • homogeneous catalysis
  • iron

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